Ruthenium mercapto/nitrosyl complexes: in vitro and in vivo evaluation of antitumor activiili

• Grant number: 22/11924-8
• Support Opportunities: Scholarships in Brazil - Doctorate (Direct)
• Start date: December 01, 2022
• End date: November 30, 2024
• Field of knowledge: Physical Sciences and Mathematics - Chemistry - Inorganic Chemistry
• Agreement: CNPq - Pronex
• Principal Investigator: Alzir Azevedo Batista
• Grantee: Alex Marchezini Graça
• Host Institution: Centro de Ciências Exatas e de Tecnologia (CCET). Universidade Federal de São Carlos (UFSCAR). São Carlos , SP, Brazil
• Associated research grant: 17/15850-0 - X-ray diffraction as a tool in potential drug development, AP.TEM

Abstract

The development of metallic compounds, in order to find new drug candidates for the treatment of cancer, has gained increasing importance in the scientific field, given that this disease is a serious worldwide public health problem . For this, several transition metals have been used, seeking to identify more selective and effective compounds, without side effects. In particular, ruthenium-based compounds have shown promising cytotoxic properties, which has encouraged many research groups to develop studies focused on this metal. In this context,the present work plan consists of the investigation of the antitumor potential of ruthenium complexes, through in vitro and in vivo assays, being an integral part of our thematic project "X-Ray Diffraction as a Tool in Potential Drug Development" ( 2017/15850-0). (AU)

Scientific publications

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

LEITE, CELISNOLIA M.; ARAUJO-NETO, JOAO H.; GUEDES, ADRIANA P. M.; COSTA, ANALU R.; DEMIDOFF, FELIPE C.; NETTO, CHAQUIP D.; CASTELLANO, EDUARDO E.; NASCIMENTO, OTACIRO R.; BATISTA, ALZIR A.. Copper(I)/Triphenylphosphine Complexes Containing Naphthoquinone Ligands as Potential Anticancer Agents. INORGANICS, v. 11, n. 9, p. 18-pg., 2023-09-01. (17/15850-0, 22/11924-8, 20/14561-8)