The use of proteomics and RNA-seq techniques for analysis of cancer cachexia associated with the treatment of nanoparticles and aerobic physical exercise

• Grant number: 22/13577-3
• Support Opportunities: Scholarships abroad - Research Internship - Master's degree
• Start date: June 09, 2023
• End date: December 08, 2023
• Field of knowledge: Health Sciences - Physical Education
• Principal Investigator: Giovana Rampazzo Teixeira
• Grantee: Rafael Ribeiro Correia
• Supervisor: Teresa Zimmers
• Host Institution: Faculdade de Ciências e Tecnologia (FCT). Universidade Estadual Paulista (UNESP). Campus de Presidente Prudente. Presidente Prudente , SP, Brazil
• Institution abroad: Oregon Health & Science University, United States
• Associated to the scholarship: 21/14514-2 - Analysis of cancer cachexia associated with the treatment of drug-carrying nanoparticles of docetaxel and methotrexate in sprague-dawley rats submitted to aerobic physical training, BP.MS

Abstract

Cachexia is defined as a multifactorial syndrome characterized by the continuous loss of skeletal muscle mass (with or without loss of adipose tissue) that is not reversed by conventional nutritional support and leads to progressive functional impairment. The principal objective of this internship proposal is complementary to Brazilian research, where we evaluated the effects of cancer cachexia and its treatment with nanoparticles that carry chemotherapeutic agents associated with aerobic exercise. For this, we will carry out to realize the analysis of the tibialis anterior muscle through proteomic and RNA-seq techniques of cachectic animals and to find what parameters are downstream and/or upstream when compared with the control group. (AU)