Melatonin as potentiator of the physical training effects on biomolecular parameters of energy metabolism under hypoestrogenism

• Grant number: 21/03951-2
• Support Opportunities: Scholarships in Brazil - Doctorate
• Start date: January 01, 2023
• End date: June 22, 2026
• Field of knowledge: Health Sciences - Physical Education
• Principal Investigator: Wladimir Rafael Beck
• Grantee: Taciane Maria Melges Pejon
• Host Institution: Centro de Ciências Biológicas e da Saúde (CCBS). Universidade Federal de São Carlos (UFSCAR). São Carlos , SP, Brazil

Abstract

Hypoestrogenism state can leads to metabolic diseases through an impairment in energy balance adjustment. Skeletal muscle is the main responsible for daily energy expenditure and at the molecular level, this hormonal deficit can compromise the content of GLUT4, FAT CD36, PGC-1±, NRF-1, and AMPK, impairing crucial metabolic functions in such tissue. Thus, this proposal will seek to analyze the effects of moderate and individualized physical training under hypoestrogenism. However, given the powerful harmful effect of hypoestrogenism on energy metabolism, the literature identifies that certain physical training protocols do not have enough effectiveness, capable of potentiating the results of the evaluated parameters. Thus, the inclusion of a pharmacological method that presents practically despicable side effects in view of its great beneficial potential is certainly an alternative to be investigated. Melatonin has been shown to be a relevant pharmacological tool for energy regulation, presenting very satisfactory results on metabolic disorders. However, its behavior isolated or added to physical training on metabolic parameters in hypoestrogenism condition is unknown, especially regarding the crucial muscle proteins previously cited. Thus, our proposal is to investigate the effects of melatonin and aerobic training on metabolic parameters commonly compromised by hypoestrogenism. The hypothesis is that melatonin will potentiate the effects of physical training on skeletal muscle tissue functioning, mainly by inducing the synthesis of GLUT4, FAT CD36, PGC-1±, NRF-1, and AMPK, in addition to stimulating energy expenditure. Such a scenario could prevent the emergence of relevant metabolic diseases. Furthermore, regardless of the results, these findings will help to understand the physiological mechanisms by which melatonin acts in skeletal muscle energy regulation, in addition to its systemic repercussion, active and relevant field of investigation.

Scientific publications

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

BECK, WLADIMIR RAFAEL; SCARIOT, PEDRO PAULO MENEZES; PAPOTI, MARCELO; PEJON, TACIANE MARIA MELGES; POLISEL, EMANUEL ELIAS CAMOLESE; MANCHADO-GOBATTO, FULVIA BARROS; GOBATTO, CLAUDIO ALEXANDRE. Living High-Training Low on Mice Bone Parameters Analyzed through Complex Network Approach. INTERNATIONAL JOURNAL OF SPORTS MEDICINE, v. N/A, p. 9-pg., 2024-11-13. (19/05115-7, 17/10201-4, 15/00272-6, 21/03951-2, 19/20930-9, 15/01362-9, 19/08148-3)

PEJON, TACIANE MARIA MELGES; MESSIAS, LEONARDO HENRIQUE DALCHECO; NASCIMENTO, RAFAEL HENRIQUE; BERTOLUCCI, VANESSA; NINOMIYA, ANDRE FELIPE; BECK, WLADIMIR RAFAEL. Melatonin administration on bone properties of animals under hypoestrogenism: A systematic review. REVIEWS IN ENDOCRINE & METABOLIC DISORDERS, v. N/A, p. 13-pg., 2025-02-26. (21/03951-2)