Clinicopathological and digital predictors of recurrence and malignancy of oral leukoplakia and proliferative verrucous leukoplakia: a clinical trial associated with the use of artificial intelligence

• Grant number: 22/07276-0
• Support Opportunities: Scholarships in Brazil - Doctorate
• Start date: April 01, 2023
• Status: Discontinued
• Field of knowledge: Health Sciences - Dentistry
• Principal Investigator: Marcio Ajudarte Lopes
• Grantee: Caique Mariano Pedroso
• Host Institution: Faculdade de Odontologia de Piracicaba (FOP). Universidade Estadual de Campinas (UNICAMP). Piracicaba , SP, Brazil
• Associated scholarship(s): 24/18766-4 - Using self-supervised learning to predict recurrence and malignant transformation of oral leukoplakia stratified according to type of treatment, BE.EP.DR

Abstract

Oral leukoplakia (OL) and proliferative verrucous leukoplakia (PVL) are oral potentially malignant disorders (OPMD) that require surgical treatment when presenting with epithelial dysplasia. However, the recurrence and malignancy rates of OL and PVL persist high and remain a clinical challenge for patients and professionals involved in the treatment. Moreover, currently, the use of artificial intelligence (AI), through prognostic models, is an important method to auxiliary predict the risk of OPMD malignancy. Therefore, this study aims to evaluate the performance of surgical treatment by comparing two modalities (diode laser and scalpel) in reducing the rates of recurrence and malignancy of OL and PVL, as well as, to analyze the performance of a predictive model via deep learning neural networks for recurrence and malignancy of OL and PVL after treatment. This study is designated as an adjunctive randomized clinical trial to an AI study. One hundred and twenty patients diagnosed with OL and PVL will be randomized into 4 treatment arms: (1) OL treated with a diode laser (n=30); (2) OL treated by scalpel (n=30); (3) PVL treated with a diode laser (n=30) and (4) PVL treated by scalpel (n=30). Follow-up of patients recruited and enrolled in the clinical study will be performed at a three-monthly frequency for 24 months for clinical evaluation of the clinical outcomes of the interventions. Based on deep learning neural networks, sociodemographic data, clinical and histopathological photos of the clinical trial patients will be used to investigate the clinical outcomes. It is expected that the diode laser will show a decrease in recurrence and malignancy rates of OL and PVL when compared to the scalpel, and AI may help predict the risk of recurrence and malignancy of OL and PVL

Scientific publications

(5)

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

ARAUJO, ANNA LUIZA DAMACENO; MORAES, MATHEUS CARDOSO; PEREZ-DI-OLIVEIRA, MARIA EDUARDA; DA SILVA, VIVIANE MARIANO; SALDIVIA-SIRACUSA, CRISTINA; PEDROSO, CAIQUE MARIANO; LOPES, MARCIO AJUDARTE; VARGAS, PABLO AGUSTIN; KOCHANNY, SARA; PEARSON, ALEXANDER; et al. Machine learning for the prediction of toxicities from head and neck cancer treatment: A systematic review with meta-analysis. Oral Oncology, v. 140, p. 15-pg., 2023-04-04. (22/07276-0, 21/14585-7, 09/53839-2)

PEDROSO, CAIQUE MARIANO; DO SANTOS, ERISON SANTANA; ALVES, FABIO ABREU; MARTINS, MANOELA DOMINGUES; KOWALSKI, LUIZ PAULO; LOPES, MARCIO AJUDARTE; WARNAKULASURIYA, SAMAN; VILLA, ALESSANDRO; SANTOS-SILVA, ALAN ROGER. Surgical protocols for oral leukoplakia and precancerous lesions across three different anatomic sites. ORAL DISEASES, v. N/A, p. 10-pg., 2024-08-18. (22/07276-0)

PAGLIONI, MARIANA DE PAULI; PEDROSO, CAIQUE MARIANO; FAUSTINO, ISABEL SCHAUSLTZ PEREIRA; VARGAS, PABLO AGUSTIN; DE GOES, MARIO FERNANDO; MARTINS, MANOELA DOMINGUES; LOPES, MARCIO AJUDARTE; SANTOS-SILVA, ALAN ROGER. Wound healing and pain evaluation following diode laser surgery vs. conventional scalpel surgery in the surgical treatment of oral leukoplakia: a randomized controlled trial. FRONTIERS IN ORAL HEALTH, v. 6, p. 9-pg., 2025-03-03. (22/07276-0)

ARAUJO, ANNA LUIZA DAMACENO; DE SOUZA, EDUARDO SANTOS CARLOS; FAUSTINO, ISABEL SCHAUSLTZ PEREIRA; SALDIVIA-SIRACUSA, CRISTINA; BRITO-SARRACINO, TAMIRES; ADUDURATE LOPES, MARCIO; VARGAS, PABLO AGUSTIN; PEARSON, ALEXANDER T.; KOWALSKI, LUIZ PAULO; DE CARVALHO, ANDRE CARLOS PONCE DE LEON FERREIRA; et al. Clinicians' perception of oral potentially malignant disorders: a pitfall for image annotation in supervised learning. ORAL SURGERY ORAL MEDICINE ORAL PATHOLOGY ORAL RADIOLOGY, v. 136, n. 3, p. 7-pg., 2023-09-01. (22/07276-0, 21/14585-7, 09/53839-2)

PAGLIONI, MARIANA DE PAULI; FAUSTINO, ISABEL SCHAUSLTZ PEREIRA; PEDROSO, CAIQUE MARIANO; MARTINS, MANOELA DOMINGUES; VARGAS, PABLO AUGUSTIN; LOPES, MARCIO AJUDARTE; SANTOS-SILVA, ALAN ROGER. Oral leukoplakia treated with laser and scalpel: Interim trial results of recurrence and malignancy. ORAL DISEASES, v. N/A, p. 4-pg., 2024-04-24. (22/07276-0)