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3D-PRINTING AND TEXTILE THREADS-BASED MICROFLUIDIC PLATFORMS FOR ELECTROANALYSIS OF CLINICAL, ENVIRONMENTAL AND BIOLOGICAL SAMPLES

Grant number: 22/01810-5
Support Opportunities:Scholarships in Brazil - Post-Doctoral
Effective date (Start): June 01, 2023
Status:Discontinued
Field of knowledge:Physical Sciences and Mathematics - Chemistry - Analytical Chemistry
Principal Investigator:Thiago Regis Longo Cesar da Paixão
Grantee:Diele Aparecida Gouveia Araújo
Host Institution: Instituto de Química (IQ). Universidade de São Paulo (USP). São Paulo , SP, Brazil
Associated research grant:18/08782-1 - Miniaturized and integrated chemical sensors: new fabrication platforms for biological, clinical and environmental applications, AP.TEM
Associated scholarship(s):23/16658-7 - DEVELOPMENT OF CAPILLARY FLOW-DRIVEN MICROFLUIDIC DEVICES COUPLING SAMPLE PREPARATION AND ELECTROCHEMICAL DETECTION, BE.EP.PD

Abstract

The search for portable devices that allow the development of environmentally safer analytical methods and real-time information collection to carry out "in loco" analyses is a current trend in analytical chemistry. Microfluidic systems are an attractive strategy to achieve these goals. In addition to allowing studies with low sample volumes, they enable the integration of analytical steps in the same platform. In this sense, this project consists of developing more robust microfluidic systems using textile yarns and 3D printing to achieve reproducible and reliable analyses together with greater portability and low cost. To circumvent some limitations presented in the literature related to microfluidic channels based on textile yarns, 3D printing will create a compartment for the microfluidic channel to minimize the solvent evaporation process and provide constant flow during all analyses. The electrochemical sensors will also be built using a 3D printer and integrated into the microfluidic channel compartment, facilitating the detection step. Cotton wads will be added to the outlet reservoir to increase the system's absorbent capacity. In addition, the outlet reservoir can be easily renewed by simply changing the cotton, without the need to assemble/disassemble the entire system, a standard feature for platforms based on paper and textile yarns proposed in the literature. Finally, the analytical performance of the proposed platform will be evaluated in the analysis of samples of environmental, clinical, and biological interest.

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