Miniaturized and integrated chemical sensors: new fabrication platforms for biological, clinical and environmental applications

• Grant number: 18/08782-1
• Support Opportunities: Research Projects - Thematic Grants
• Start date: December 01, 2018
• End date: November 30, 2023
• Field of knowledge: Physical Sciences and Mathematics - Chemistry - Analytical Chemistry
• Principal Investigator: Mauro Bertotti
• Grantee: Mauro Bertotti
• Host Institution: Instituto de Química (IQ). Universidade de São Paulo (USP). São Paulo , SP, Brazil
• Pesquisadores principais: Marcelo Nelson Páez Carreño ; Thiago Regis Longo Cesar da Paixão
• Associated researchers: Gustavo Pamplona Rehder ; Ines Pereyra ; Marco Isaías Alayo Chávez ; William Reis de Araujo
• Associated research grant(s): 19/16491-0 - Rapid, onsite detection of toxic metals combining paper-based electrochemical sensors and fast-scan cyclic voltammetry, AP.R SPRINT; 19/10606-0 - Multi-User Equipment approved in grant 2018/08782-1: photolithography system, AP.EMU; 19/00811-5 - EMU granted in process 2018/08782-1: materials deposition system by ink-jet, AP.EMU
• Associated scholarship(s): 22/01810-5 - 3D-PRINTING AND TEXTILE THREADS-BASED MICROFLUIDIC PLATFORMS FOR ELECTROANALYSIS OF CLINICAL, ENVIRONMENTAL AND BIOLOGICAL SAMPLES, BP.PD; 23/02572-3 - Using a portable potentiostat to get chemical information in rat brain, BP.TT; 22/14473-7 - Modification of electrodic surfaces with porphyrazines towards the development of a nitric oxide electrochemical sensor, BP.IC; + associated scholarships 22/03643-9 - Study of the effect of ascorbic acid on protection against UV radiation in cells through the development of electrochemical nanosensors for localized and real-time detection, BP.DD; 22/04980-9 - Calibration-free electrochemical microsensors for milk analysis, BP.DD; 22/03665-2 - Electrochemical sensors for hydrogen peroxide and calcium ions detection in biological systems, BP.DD; 22/03382-0 - Wearable sensor for real time monitoring of drugs of abuse in human saliva, BP.PD; 22/00064-8 - An electrochemical sensor for phosphate detection in water samples, BP.IC; 21/00205-8 - Miniaturized and/or microfluidic analytical devices for biological applications, BP.PD; 21/05806-0 - Portable miniaturized potentiostat with wireless communication: hardware components, BP.TT; 21/09798-1 - Portable miniaturized potentiostat with wireless communication: hardware components, BP.TT; 20/01612-3 - Study on Ca2+ diffusion through caffeine-containing xantana membranes using a potentiometric microsensor, BP.IC; 19/23206-0 - Fabrication on an electrochemical sensor for no detection, BP.IC; 19/15065-7 - Development of paper-based electrochemical systems aiming flow analysis of forensic samples, BP.DD; 19/14418-3 - Electrochemical sensors for water quality monitoring, BP.DD; 19/06293-6 - Investigations in biological systems by using miniaturized electrochemical sensors, BP.PD; 19/00889-4 - Electrochemical determination of iodate in urine samples by redox cycling with microelectrodes, BP.MS - associated scholarships

Abstract

Analytical chemistry techniques and technologies have rapidly emerged in the last years, but the cost and logistics for the samples collection at meaningful spatial scales and further analysis does not make their development and spread straightforward. Such problems can be better addressed by the fabrication of devices that operate autonomously at or near the sampling site, reducing the risks of error and contamination associated with manual sample acquisition, storage, and transport. This direct-reading chemical sensor operates by detecting and responding in a fast way to the presence or amount of an analyte at some interface between the sensor and the sample matrix. Those systems are capable of handling volumes on the microliter level and performing assays at short times, hence the miniaturization offers a suitable platform for portability and automation. Based on selected parameters, devices can be fabricated for analog signal gathering, processing, logging and remote presentation of data. Taking into account the above-mentioned, this research project aims at designing and developing integrated systems for real time monitoring of some target compounds at sites of environmental, health and biological relevance. The proposed devices will consist of several miniaturized electrochemical and optical sensors and emphasis will be given on apparatuses that can be easily implemented and possess reliable and long-time operation, as well as with wearable application. To achieve high selectivity toward the desired analytes, new platforms will be designed by using novel materials. In the absence of favorable selectivity, different strategies will be employed such as mathematical approaches (chemometric analysis) or the separation of the analyte from the sample matrix by using microfluidic devices. The developed sensors will have to satisfy analytical requirements (e.g. reduced drift response, resistance to surface fouling and high selectivity, accuracy and precision) as well as technological demands (mass-scale production at low cost, low power requirements and robust electronics). (AU)

Scientific publications

(73)

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

MENDES, LETICIA FRANCINE; DE SIERVO, ABNER; DE ARAUJO, WILLIAM REIS; LONGO CESAR PAIXAO, THIAGO REGIS. Reagentless fabrication of a porous graphene-like electrochemical device from phenolic paper using laser-scribing. Carbon, v. 159, p. 110-118, APR 15 2020. (17/10522-5, 18/08782-1, 07/54829-5, 18/16250-0)

ATAIDE, VANESSA N.; MENDES, LETICIA F.; GAMA, LILLIA I. L. M.; DE ARAUJO, WILLIAM R.; PAIXAO, THIAGO R. L. C.. Electrochemical paper-based analytical devices: ten years of development. ANALYTICAL METHODS, v. 12, n. 8, p. 1030-1054, FEB 28 2020. (17/10522-5, 18/14462-0, 18/08782-1, 16/16477-9, 19/16491-0)

TORRES, MARCELO D. T.; DE ARAUJO, WILLIAM R.; DE LIMA, LUCAS F.; FERREIRA, ANDRE L.; DE LA FUENTE-NUNEZ, CESAR. Low-cost biosensor for rapid detection of SARS-CoV-2 at the point of care. MATTER, v. 4, n. 7, p. 2403-2416, JUL 7 2021. (18/08782-1)

SUKERI, ANANDHAKUMAR; DE CARVALHO JUNIOR, EDUARDO JOSE; BERTOTTI, MAURO. A novel approach for one-step fabrication of platinum-nanoporous gold film via oxygen bubble template with enhanced electrochemical activity. Electrochemistry Communications, v. 100, p. 96-99, MAR 2019. (18/08782-1, 17/21585-8)

FERREIRA, ANDRE LOPES; DE LIMA, LUCAS FELIPE; TOROSSIAN TORRES, MARCELO DER; DE ARAUJO, WILLIAM REIS; DE LA FUENTE-NUNEZ, CESAR. ow-Cost Optodiagnostic for Minute-Time Scale Detection of SARS-CoV-. ACS NANO, v. 15, n. 11, p. 17453-17462, NOV 23 2021. (18/08782-1)

REGIART, MATIAS; KUMAR, ABHISHEK; GONCALVES, JOSUE M.; SILVA JUNIOR, GILBERTO J.; MASINI, JORGE CESAR; ANGNES, LUCIO; BERTOTTI, MAURO. An Electrochemically Synthesized Nanoporous Copper Microsensor for Highly Sensitive and Selective Determination of Glyphosate. CHEMELECTROCHEM, v. 7, n. 7, p. 1558-1566, APR 1 2020. (18/16896-7, 19/14418-3, 18/08782-1, 19/06293-6)

ATAIDE, VANESSA N.; AMEKU, WILSON A.; BACIL, RAPHAEL R.; ANGNES, LUCIO; DE ARAUJO, WILLIAM R.; PAIXAO, THIAGO R. L. C.. Enhanced performance of pencil-drawn paper-based electrodes by laser-scribing treatment. RSC ADVANCES, v. 11, n. 3, p. 1644-1653, JAN 13 2021. (18/14462-0, 16/21070-5, 18/08782-1, 16/16477-9, 17/10522-5)

LIMA, LUCAS F. DE; DE FREITAS, AMANDA DE S. M.; MACIEL, CRISTIANE CARLA; FERREIRA, ANDRE L.; FERREIRA, MARYSTELA; ARAUJO, WILLIAM R. DE. Enzymeless glucose sensor based on disposable Ecoflex?/graphite thermoplastic composite substrate modified with Au@GQDs. SENSORS AND ACTUATORS REPORTS, v. 4, p. 11-pg., 2022-11-01. (18/08782-1, 19/02692-3, 18/04061-8)

ATAIDE, VANESSA N.; ARANTES, IANA V. S.; MENDES, LETICIA F.; ROCHA, DANIELLY S.; BALDO, THAISA A.; COLTRO, WENDELL K. T.; PAIXAO, THIAGO R. L. C.. Review-A Pencil Drawing Overview: From Graphite to Electrochemical Sensors/Biosensors Applications. Journal of the Electrochemical Society, v. 169, n. 4, p. 15-pg., 2022-04-01. (18/14462-0, 18/08782-1, 18/16250-0, 19/15065-7)

CORSI, JORDAN; REHDER, GUSTAVO P.; FERRARI, PHILIPPE; SERRANO, ARIANA L. C.; PISTONO, EMMANUEL. Modeling and Design of a Partially Air-Filled Slow Wave Substrate Integrated Waveguide. IEEE Transactions on Microwave Theory and Techniques, v. N/A, p. 13-pg., 2022-09-26. (18/08782-1, 16/25779-9)

DE LIMA, LUCAS F.; FERREIRA, ANDRE L.; TORRES, MARCELO D. T.; DE ARAUJO, WILLIAM R.; DE LA FUENTE-NUNEZ, CESAR. Minute-scale detection of SARS-CoV-2 using a low-cost biosensor composed of pencil graphite electrodes. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, v. 118, n. 30, JUL 27 2021. (18/08782-1)

AMEKU, WILSON A.; DE ARAUJO, WILLIAM R.; RANGEL, CLARA J.; ANDO, ROMULO A.; PAIXAO, THIAGO R. L. C.. Gold Nanoparticle Paper-Based Dual-Detection Device for Forensics Applications. ACS APPLIED NANO MATERIALS, v. 2, n. 9, p. 5460-5468, SEP 2019. (16/21070-5, 17/10522-5, 18/08782-1, 16/16477-9)

SHAHRI, ATENA AMANATI; OMIDVAR, AMIR HOSSEIN; REHDER, GUSTAVO PAMPLONA; CANIATO SERRANO, ARIANA LACORTE. A Microwave-Based Microfluidic Cell Detecting Biosensor for Biological Quantification Using the Metallic Nanowire-Filled Membrane Technology. SENSORS, v. 22, n. 9, p. 13-pg., 2022-05-01. (16/25779-9, 18/08782-1)

AMEKU, WILSON A.; GONCALVES, JOSUE M.; ATAIDE, VANESSA N.; SANTOS, MAURO S. FERREIRA; GUTZ, IVANO G. R.; ARAKI, KOITI; PAIXAO, THIAGO R. L. C.. Combined Colorimetric and Electrochemical Measurement Paper-Based Device for Chemometric Proof-of-Concept Analysis of Cocaine Samples. ACS OMEGA, v. 6, n. 1, p. 594-605, JAN 12 2021. (17/10522-5, 19/16491-0, 16/21070-5, 18/08782-1)

ORTEGA, FRANCISCO G.; REGIART, MATIAS D.; RODRIGUEZ-MARTINEZ, ALBA; DE MIGUEL-PEREZ, DIEGO; SERRANO, MARIA J.; LORENTE, JOSE A.; TORTELLA, GONZALO; RUBILAR, OLGA; SAPAG, KARIM; BERTOTTI, MAURO; et al. Sandwich-Type Electrochemical Paper-Based Immunosensor for Claudin 7 and CD81 Dual Determination on Extracellular Vesicles from Breast Cancer Patients. Analytical Chemistry, v. 93, n. 2, p. 1143-1153, JAN 19 2021. (18/08782-1, 19/06293-6)

DIGNANI, MARCELLA T.; BIONI, THAIS A.; PAIXAO, THIAGO R. L. C.; EL SEOUD, OMAR A.. Cellulose Dissolution in Mixtures of Ionic Liquids and Dimethyl Sulfoxide: A Quantitative Assessment of the Relative Importance of Temperature and Composition of the Binary Solvent. Molecules, v. 25, n. 24, DEC 2020. (14/22136-4, 19/02928-7, 19/16491-0, 18/08782-1)

STEFANO, JESSICA SANTOS; ORZARI, LUIZ OTAVIO; SILVA-NETO, HABDIAS ARAUJO; DE ATAIDE, VANESSA NEIVA; MENDES, LETICIA FRANCINE; TOMAZELLI COLTRO, WENDELL KARLOS; CESAR PAIXAO, THIAGO REGIS LONGO; JANEGITZ, BRUNO CAMPOS. Different approaches for fabrication of low-cost electrochemical sensors. CURRENT OPINION IN ELECTROCHEMISTRY, v. 32, p. 9-pg., 2022-04-01. (18/08782-1, 18/16250-0, 18/14462-0, 17/21097-3)

SILVA, THALITA GUEDES; LONGO CESAR DA PAIXAO, THIAGO REGIS. Development and Evaluation of Two Different Electronic Tongues Aiming to the Discrimination of Cutting Agents Found in Cocaine Seized Samples. BRAZILIAN JOURNAL OF ANALYTICAL CHEMISTRY, v. 9, n. 34, p. 10-pg., 2022-01-01. (18/08782-1, 19/16491-0, 17/10522-5)

DE LIMA, LUCAS F.; DE ARAUJO, WILLIAM R.. Laser-scribed graphene on polyetherimide substrate: an electrochemical sensor platform for forensic determination of xylazine in urine and beverage samples. Microchimica Acta, v. 189, n. 12, p. 11-pg., 2022-12-01. (18/08782-1)

DE LIMA, LUCAS F.; FERREIRA, ANDRE L.; MACIEL, CRISTIANE C.; FERREIRA, MARYSTELA; DE ARAUJO, WILLIAM R.. Disposable and low-cost electrochemical sensor based on the colorless nail polish and graphite composite material for tartrazine detection. Talanta, v. 227, MAY 15 2021. (19/02692-3, 18/08782-1, 18/04061-8)

NEGAHDARY, MASOUD; VELOSO, WILLIAM BARROS; BACIL, RAPHAEL PRATA; BUORO, RAFAEL MARTOS; GUTZ, IVANO GEBHARDT ROLF; PAIXAO, THIAGO REGIS LONGO CESAR; DO LAGO, CLAUDIMIR LUCIO; SAKATA, SOLANGE KAZUMI; MELONI, GABRIEL NEGRAO; FRANCA, MESAQUE CARVALHO; et al. Aptasensing of beta-amyloid (Aβ_(1-42)) by a 3D-printed platform integrated with leaf-shaped gold nanodendrites. SENSORS AND ACTUATORS B-CHEMICAL, v. 393, p. 11-pg., 2023-10-15. (19/27021-4, 17/13137-5, 18/08782-1, 14/50867-3)

DE LIMA, LUCAS F.; DE ARAUJO, WILLIAM R.. A highly efficient and portable laser-scribed graphene-based electrochemical system for forensic-oriented determination of acepromazine. ANALYTICAL METHODS, v. 15, n. 35, p. 10-pg., 2023-09-14. (22/03250-7, 18/08782-1)

FRUTUOSO, TADEU M.; LE, JOAO; BERTHOUD, YOANN; PINHEIRO, JULIO M.; MARGALEF-ROVIRA, MARC; FERRARI, PHILIPPE; REHDER, GUSTAVO P.; SERRANO, ARIANA L. C.. Nanowire-Based 3-D Transmission-Line Transformer for Millimeter-Wave Applications. IEEE MICROWAVE AND WIRELESS COMPONENTS LETTERS, v. 32, n. 10, p. 4-pg., 2022-05-05. (16/25779-9, 18/08782-1)

ARJUNAN, ANANTHI; SUKERI, ANANDHAKUMAR; SARAIVA, DOUGLAS PHILIP MARTINEZ; MIRANDA, PAULO BARBEITAS; BERTOTTI, MAURO. Electrochemical Studies of Hydrogen Peroxide Oxidation on a Nanoporous Gold Surface: Fundamental and Analytical Applications. Journal of the Electrochemical Society, v. 167, n. 11, JAN 8 2020. (18/08782-1, 18/02819-0)

GROTHE, RENATA A.; LOBATO, ALNILAN; MOUNSSEF, BASSIM; TASI, NIKOLA; BRAGA, ATAUALPA A. C.; MALDANER, ADRIANO O.; ALDOUS, LEIGH; PAIXAO, THIAGO R. L. C.; GONCALVES, LUIS MOREIRA. Electroanalytical profiling of cocaine samples by means of an electropolymerized molecularly imprinted polymer using benzocaine as the template molecule. ANALYST, v. 146, n. 5, p. 1747-1759, MAR 7 2021. (19/05569-8, 18/13922-7, 14/25770-6, 15/01491-3, 18/14425-7, 18/08782-1, 19/11214-8)

TASIC, NIKOLA; CAVALCANTE, LETICIA; DEFFUNE, ELENICE; GOES, MARCIO SOUSA; PAIXAO, THIAGO R. L. C.; GONCALVES, LUIS MOREIRA. Probeless and label-free impedimetric biosensing of D-dimer using gold nanoparticles conjugated with dihexadecylphosphate on screen-printed carbon electrodes. Electrochimica Acta, v. 397, NOV 20 2021. (18/13922-7, 18/08782-1, 17/10522-5, 18/14425-7)

SOARES, MARCO; AMATO, FRANCESCO; CABRAL, THIAGO; CACIOPPO, MICHELE; CARRENO, MARCELO; PEREYRA, INES; RAMOS, CARLOS; CID, MANUEL; GOVEIA, GILSON; CHUBACI, JOSE; et al. Improving Solar Cells Efficiency with PMMA-Carbon Dots Nanocomposites. 2023 INTERNATIONAL CONFERENCE ON OPTICAL MEMS AND NANOPHOTONICS, OMN AND SBFOTON INTERNATIONAL OPTICS AND PHOTONICS CONFERENCE, SBFOTON IOPC, v. N/A, p. 2-pg., 2023-01-01. (19/22554-4, 18/08782-1)

DE LIMA, LUCAS FELIPE; FERREIRA, ANDRE LOPES; DE FREITAS, AMANDA DE SOUSA MARTINEZ; RODRIGUES, JESSICA DE SOUZA; LEMES, ANA PAULA; FERREIRA, MARYSTELA; DE ARAUJO, WILLIAM REIS. Biodegradable and Flexible Thermoplastic Composite Graphite Electrodes: A Promising Platform for Inexpensive and Sensitive Electrochemical Detection of Creatine Kinase at the Point-of-Care. ACS APPLIED MATERIALS & INTERFACES, v. 15, n. 15, p. 13-pg., 2023-04-04. (20/12659-0, 16/19387-0, 19/02692-3, 22/03250-7, 18/08782-1, 18/04061-8)

GUIMARAES SELVA, JESSICA SOARES; BERTOTTI, MAURO. Iridium Oxides Based Potentiometric Sensor for pH Monitoring in Biological Samples. BRAZILIAN JOURNAL OF ANALYTICAL CHEMISTRY, v. 10, n. 40, p. 9-pg., 2023-07-01. (18/08782-1)

CRAPNELL, ROBERT D.; ARANTES, IANA V. S.; WHITTINGHAM, MATTHEW J.; SIGLEY, EVELYN; KALINKE, CRISTIANE; JANEGITZ, BRUNO C.; BONACIN, JULIANO A.; PAIXAO, THIAGO R. L. C.; BANKS, CRAIG E.. Utilising bio-based plasticiser castor oil and recycled PLA for the production of conductive additive manufacturing feedstock and detection of bisphenol A. GREEN CHEMISTRY, v. 25, n. 14, p. 10-pg., 2023-06-22. (19/00473-2, 22/07552-8, 17/21097-3, 18/08782-1, 21/07989-4, 19/15065-7, 13/22127-2)

PRADELA-FILHO, LAURO A. A.; VELOSO, WILLIAM B. B.; MEDEIROS, DEBORA N.; LINS, RENATO S. O.; FERREIRA, BRUNO; BERTOTTI, MAURO; PAIXAO, THIAGO R. L. C.. Patterning (Electro)chemical Treatment-Free Electrodes with a 3D Printing Pen. Analytical Chemistry, v. 95, n. 28, p. 10-pg., 2023-06-22. (21/00205-8, 19/00811-5, 18/08782-1)

PATRICIO HERNANDEZ-SARAVIA, LUCAS; MARTINEZ, TAMARA; LLANOS, JAIME; BERTOTTI, MAURO. A Cu-NPG/SPE sensor for non-enzymatic and non-invasive electrochemical glucose detection. Microchemical Journal, v. 160, n. A, JAN 2021. (18/08782-1)

ARANTES, IANA V. S.; PAIXAO, THIAGO R. L. C.. ouple batch-injection analysis and microfluidic paper-based analytical device: A simple and disposable alternative to conventional BIA apparatu. Talanta, v. 240, APR 1 2022. (17/10522-5, 19/15065-7, 18/08782-1)

KUMAR, ABHISHEK; GONCALVES, JOSUE M.; SELVA, JESSICA S. G.; ARAKI, KOITI; BERTOTTIZ, MAURO. Correlating Selective Electrocatalysis of Dopamine and Ascorbic Acid Electrooxidation at Nanoporous Gold Surfaces with Structural-Defects. Journal of the Electrochemical Society, v. 166, n. 14, p. H704-H711, SEP 30 2019. (13/24725-4, 18/08782-1)

TASIC, NIKOLA; PAIXAO, THIAGO R. L. C.; GONCALVES, LUIS MOREIRA. Biosensing of D-dimer, making the transition from the central hospital laboratory to bedside determination. Talanta, v. 207, JAN 15 2020. (17/10522-5, 18/08782-1, 18/13922-7, 18/14425-7)

KUMAR, ABHISHEK; GONCALVES, JOSUE M.; LIMA, ALAN R.; MATIAS, TIAGO A.; NAKAMURA, MARCELO; BERNARDES, JULIANA S.; ARAKI, KOITI; BERTOTTI, MAURO. Efficient and methanol resistant noble metal free electrocatalyst for tetraelectronic oxygen reduction reaction. Electrochimica Acta, v. 326, DEC 5 2019. (18/08782-1, 18/21489-1)

PIGUILLEM, SOFIA V.; REGIART, MATIAS; BERTOTTI, MAURO; RABA, JULIO; MESSINA, GERMAN A.; FERNANDEZ-BALDO, MARTIN A.. Microfluidic fluorescence immunosensor using ZnONFs for invasive aspergillosis determination. Microchemical Journal, v. 159, DEC 2020. (19/06293-6, 18/08782-1)

V. PASCHOARELLI, MAYRA V.; KAVAI, MATHIAS S.; DE LIMA, LUCAS F.; DE ARAUJO, WILLIAM R.. Laser-scribing fabrication of a disposable electrochemical device for forensic detection of crime facilitating drugs in beverage samples. Talanta, v. 255, p. 9-pg., 2022-12-26. (18/08782-1)

SILVA-NETO, HABDIAS A.; ARANTES, IANA V. S.; FERREIRA, ANDRE L.; DO NASCIMENTO, GUIDA H. M.; MELONI, GABRIEL N.; DE ARAUJO, WILLIAM R.; PAIXA, THIAGO R. L. C.; COLTRO, WENDELL K. T.. Recent advances on paper-based microfluidic devices for bioanalysis. TRAC-TRENDS IN ANALYTICAL CHEMISTRY, v. 158, p. 25-pg., 2022-12-27. (19/15065-7, 22/03382-0, 18/08782-1)

PRADELA-FILHO, LAURO A.; GONGONI, JULIANA L. M.; ARANTES, IANA V. S.; DE FARIAS, DAVI M.; PAIXAO, THIAGO R. L. C.. Controlling the Inkjet Printing Process for Electrochemical (Bio)Sensors. ADVANCED MATERIALS TECHNOLOGIES, v. N/A, p. 9-pg., 2023-01-29. (19/15065-7, 21/00205-8, 19/00811-5, 18/08782-1)

BOSSARD, BRUNA; GROTHE, RENATA ANTUNES; MARTINS, ALISSON BEZERRA; LOBATO, ALNILAN; TASIC, NIKOLA; PAIXAO, THIAGO R. L. C.; GONCALVES, LUIS MOREIRA. Nanographene laser-pyrolyzed paper electrodes for the impedimetric detection of D-glucose via a molecularly imprinted polymer. MONATSHEFTE FUR CHEMIE, v. 153, n. 12, p. 7-pg., 2022-10-14. (18/14425-7, 17/10522-5, 18/13922-7, 18/08782-1, 19/11214-8)

KUMAR, ABHISHEK; SELVA, JESSICA S. G.; GONCALVES, JOSUE M.; ARAKI, KOITI; BERTOTTI, MAURO. Nanoporous gold-based dopamine sensor with sensitivity boosted by interferant ascorbic acid. Electrochimica Acta, v. 322, NOV 1 2019. (18/08782-1)

SUKERI, ANANDHAKUMAR; ARJUNAN, ANANTHI; BERTOTTI, MAURO. New strategy to fabricate a polydopamine functionalized self-supported nanoporous gold film electrode for electrochemical sensing applications. Electrochemistry Communications, v. 110, JAN 2020. (14/15215-5, 18/08782-1)

FERREIRA E SILVA, RAFAEL; LONGO CESAR PAIXAO, THIAGO REGIS; TOROSSIAN TORRES, MARCELO DER; DE ARAUJO, WILLIAM REIS. Simple and inexpensive electrochemical paper-based analytical device for sensitive detection of Pseudomonas aeruginosa. SENSORS AND ACTUATORS B-CHEMICAL, v. 308, APR 1 2020. (17/11398-6, 17/10522-5, 18/08782-1, 16/16477-9)

HERNANDEZ-SARAVIA, LUCAS PATRICIO; SUKERI, ANANDHAKUMAR; BERTOTTI, MAURO. Fabrication of nanoporous gold-islands via hydrogen bubble template: An efficient electrocatalyst for oxygen reduction and hydrogen evolution reactions. INTERNATIONAL JOURNAL OF HYDROGEN ENERGY, v. 44, n. 29, p. 15001-15008, JUN 7 2019. (18/08782-1)

FREITAS, RAFAELA C.; ORZARI, LUIZ O.; FERREIRA, LUIS M. C.; PAIXAO, THIAGO R. L. C.; COLTRO, WENDELL K. T.; VICENTINI, FERNANDO C.; JANEGITZ, BRUNO C.. Electrochemical determination of melatonin using disposable self-adhesive inked paper electrode. JOURNAL OF ELECTROANALYTICAL CHEMISTRY, v. 897, SEP 15 2021. (17/21097-3, 19/24428-6, 19/23342-0, 18/08782-1)

BALDO, THAISA A.; DE LIMA, LUCAS FELIPE; MENDES, LETICIA F.; DE ARAUJO, WILLIAM R.; PAIXAO, THIAGO R. L. C.; COLTRO, WENDELL K. T.. Wearable and Biodegradable Sensors for Clinical and Environmental Applications. ACS APPLIED ELECTRONIC MATERIALS, v. 3, n. 1, p. 68-100, JAN 26 2021. (18/16250-0, 18/08782-1, 19/16491-0)

DIP GANDARILLA, ARIAMNA MARIA; REGIART, MATIAS; BERTOTTI, MAURO; CORREA GLORIA, JULIANE; MORAIS MARIUBA, LUIS ANDRE; BRITO, WALTER RICARDO. One-step enzyme-free dual electrochemical immunosensor for histidine-rich protein 2 determination. RSC ADVANCES, v. 11, n. 1, p. 408-415, JAN 1 2021. (18/08782-1, 19/06293-6)

KUMAR, ABHISHEK; FURTADO, VINICIUS L.; GONCALVES, JOSUE M.; BANNITZ-FERNANDES, RENATA; NETTO, LUIS EDUARDO S.; ARAKI, KOITI; BERTOTTI, MAURO. Amperometric microsensor based on nanoporous gold for ascorbic acid detection in highly acidic biological extracts. Analytica Chimica Acta, v. 1095, p. 61-70, JAN 25 2020. (18/08782-1, 18/21489-1, 18/09027-2)

FERREIRA, PATRICK CESAR; ATAIDE, VANESSA NEIVA; SILVA CHAGAS, CYRO LUCAS; ANGNES, LUCIO; TOMAZELLI COLTRO, WENDELL KARLOS; LONGO CESAR PAIXAO, THIAGO REGIS; DE ARAUJO, WILLIAM REIS. Wearable electrochemical sensors for forensic and clinical applications. TRAC-TRENDS IN ANALYTICAL CHEMISTRY, v. 119, OCT 2019. (18/14462-0, 17/10522-5, 16/16477-9, 18/08782-1)

DIAS, ANDERSON A.; CHAGAS, CYRO L. S.; SILVA-NETO, HABDIAS DE A.; LOBO-JUNIOR, EULICIO O.; SGOBBI, LIVIA F.; DE ARAUJO, WILLIAM R.; PAIXAO, THIAGO R. L. C.; COLTRO, WENDELL K. T.. Environmentally Friendly Manufacturing of Flexible Graphite Electrodes for a Wearable Device Monitoring Zinc in Sweat. ACS APPLIED MATERIALS & INTERFACES, v. 11, n. 43, p. 39484-39492, OCT 30 2019. (17/10522-5, 18/08782-1)

OLIVEIRA, R. A. R.; PURIFICACAO, D. D.; PEREYRA, I.; CARRENO, M. N. P.; IEEE. Characterization of silicon thin films obtained by MicroHeater MEMS based-microLPCVD technique. 2022 36TH SYMPOSIUM ON MICROELECTRONICS TECHNOLOGY (SBMICRO 2022), v. N/A, p. 4-pg., 2022-01-01. (18/08782-1)

OMIDVAR, AMIR HOSSEIN; SHAHRI, ATENA AMANATI; CANIATO SERRANO, ARIANA LACORTE; GRUBER, JONAS; REHDER, GUSTAVO PAMPLONA. A Highly Sensitive Molecularly Imprinted Polymer (MIP)-Coated Microwave Glucose Sensor. SENSORS, v. 22, n. 22, p. 15-pg., 2022-11-01. (16/25779-9, 18/08782-1)

CLARK, KAYLEE M.; SKRAJEWSKI, LAUREN; BENAVIDEZ, TOMAS E.; MENDES, LETICIA F.; BASTOS, ERICK L.; DORR, FELIPE A.; SACHDEVA, RAKESH; OGALE, AMOD A.; PAIXAO, THIAGO R. L. C.; GARCIA, CARLOS D.. Fluorescent patterning of paper through laser engraving. SOFT MATTER, v. 16, n. 33, p. 7659-7666, SEP 7 2020. (18/16250-0, 18/08782-1)

REGIART, MATIAS; GIMENEZ, ALBA MARINA; LOPES, ALEXANDRE T.; CARRENO, MARCELO N. P.; BERTOTTI, MAURO. Ultrasensitive microfluidic electrochemical immunosensor based on electrodeposited nanoporous gold for SOX-2 determination. Analytica Chimica Acta, v. 1127, p. 122-130, AUG 29 2020. (18/08782-1, 19/06293-6)

ROCHA, DIEGO P.; ATAIDE, VANESSA N.; DE SIERVO, ABNER; GONSALVES, JOSUE M.; MUNOZ, RODRIGO A. A.; PAIXA, THIAGO R. L. C.; ANGNES, LUCIO. Reagentless and sub-minute laser-scribing treatment to produce enhanced disposable electrochemical sensors via additive manufacture. CHEMICAL ENGINEERING JOURNAL, v. 425, DEC 1 2021. (07/08244-5, 18/14462-0, 07/54829-5, 18/16896-7, 14/50867-3, 18/08782-1, 20/00325-0)

SILVA, FABIANA F.; SANTOS, CARLA S.; MELONI, GABRIEL N.; LIMA, ALEX S.; BERTOTTI, MAURO. Increased Sensitivity of Ascorbate Detection by Mediated Oxidation in Confined Electrochemical Cells. Electroanalysis, v. N/A, p. 7-pg., 2022-06-02. (18/08782-1, 19/00889-4)

REGIART, MATIAS; GIMENEZ, ALBA MARINA; MARQUES, RODOLFO F.; SOARES, IRENE S.; BERTOTTI, MAURO. Microfluidic device based on electrodeposited Nanoporous Gold/Carbon Nanotubes for Plasmodium vivax detection. SENSORS AND ACTUATORS B-CHEMICAL, v. 340, AUG 1 2021. (16/50108-0, 19/06293-6, 18/08782-1)

SILVA JUNIOR, GILBERTO J.; GUIMARAES SELVA, JESSICA SOARES; SUKERI, ANANDHAKUMAR; GONCALVES, JOSUE M.; REGIART, MATIAS; BERTOTTI, MAURO. Fabrication of dendritic nanoporous gold via a two-step amperometric approach: Application for electrochemical detection of methyl parathion in river water samples. Talanta, v. 226, MAY 2021. (19/14418-3, 18/16896-7, 18/08782-1, 19/06293-6)

SANTOS, CARLA S.; MACEDO, FELIPE; KOWALTOWSKI, ALICIA J.; BERTOTTI, MAURO; UNWIN, PATRICK R.; DA CUNHA, FERNANDA MARQUES; MELONI, GABRIEL N.. Unveiling the contribution of the reproductive system of individual Caenorhabditis elegans on oxygen consumption by single-point scanning electrochemical microscopy measurements. Analytica Chimica Acta, v. 1146, p. 88-97, FEB 15 2021. (13/07937-8, 14/22396-6, 18/08782-1)

KAVAI, MATHIAS STAHL; DE LIMA, LUCAS FELIPE; DE ARAUJO, WILLIAM REIS. A disposable and low-cost laser-scribed graphene electrochemical sensor for simultaneous detection of hydroquinone, paracetamol and methylparaben. Materials Letters, v. 330, p. 4-pg., 2023-01-01. (18/08782-1)

SPOSITO, HEITOR GABRIEL MARTINS; LOBATO, ALNILAN; TASIC, NIKOLA O.; MALDANER, ADRIANO O.; PAIXAO, THIAGO R. L. C.; GONCALVES, LUIS MOREIRA. Swift electrochemical sensing of diltiazem employing highly-selective molecularly-imprinted 3-amino-4-hydroxybenzoic acid. JOURNAL OF ELECTROANALYTICAL CHEMISTRY, v. 911, p. 7-pg., 2022-03-11. (18/13922-7, 18/14425-7, 19/16491-0, 19/11214-8, 17/10522-5, 18/08782-1, 20/04268-1)

ATAIDE, VANESSA N.; PRADELA-FILHO, LAURO A.; AMEKU, WILSON A.; NEGAHDARY, MASOUD; OLIVEIRA, THAWAN G.; SANTOS, BERLANE G.; PAIXAO, THIAGO R. L. C.; ANGNES, LUCIO. Paper-based electrochemical biosensors for the diagnosis of viral diseases. Microchimica Acta, v. 190, n. 7, p. 17-pg., 2023-07-01. (19/22126-2, 18/16896-7, 18/08782-1, 14/50867-3, 21/00205-8, 18/14462-0, 17/13137-5)

SARAIVA, DOUGLAS P. M.; BRAGA, DANIEL V.; BOSSARD, BRUNA; BERTOTTI, MAURO. Multiple Pulse Amperometry-An Antifouling Approach for Nitrite Determination Using Carbon Fiber Microelectrodes. Molecules, v. 28, n. 1, p. 11-pg., 2023-01-01. (18/08782-1)

PRADELA FILHO, LAURO A.; PAIXAO, THIAGO R. L. C.; NORDIN, GREGORY P.; WOOLLEY, ADAM T.. Leveraging the third dimension in microfluidic devices using 3D printing: no longer just scratching the surface. ANALYTICAL AND BIOANALYTICAL CHEMISTRY, v. N/A, p. 7-pg., 2023-07-20. (18/08782-1, 22/11346-4)

VELOSO, WILLIAM B.; PAIXAO, THIAGO R. L. C.; MELONI, GABRIEL N.. 3D printed electrodes design and voltammetric response. Electrochimica Acta, v. 449, p. 8-pg., 2023-03-15. (18/08782-1, 22/03382-0)

SELVA, JESSICA S. G.; VOLTARELLI, VANESSA A.; BRUM, PATRICIA C.; BERTOTTI, MAURO. SECM investigation on pH changes in cellular environment induced by caffeine. Electrochimica Acta, v. 444, p. 6-pg., 2023-02-10. (17/13133-0, 20/12514-2, 18/08782-1)

SELVA, JESSICA S. G.; SUKERI, ANANDHAKUMAR; BACIL, RAPHAEL P.; SERRANO, SILVIA H. P.; BERTOTTI, MAURO. Electrocatalysis of the hydrogen oxidation reaction on a platinum-decorated nanoporous gold surface studied by scanning electrochemical microscopy. JOURNAL OF ELECTROANALYTICAL CHEMISTRY, v. 934, p. 7-pg., 2023-03-08. (18/16896-7, 18/08782-1)

FRACHINI, EMILLI C. G.; SELVA, JESSICA S. G.; FALCOSWKI, PAULA C.; SILVA, JEAN B.; CORNEJO, DANIEL R.; BERTOTTI, MAURO; ULRICH, HENNING; PETRI, DENISE F. S.. Caffeine Release from Magneto-Responsive Hydrogels Controlled by External Magnetic Field and Calcium Ions and Its Effect on the Viability of Neuronal Cells. POLYMERS, v. 15, n. 7, p. 22-pg., 2023-04-01. (18/13492-2, 18/07366-4, 18/08782-1)

LOPES, CARLOS E. C.; DE FARIA, LUCAS V.; ARAUJO, DIELE A. G.; RICHTER, EDUARDO M.; PAIXAO, THIAGO R. L. C.; DANTAS, LUIZA M. F.; MUNOZ, RODRIGO A. A.; DA SILVA, IRANALDO S.. Lab-made 3D-printed electrochemical sensors for tetracycline determination. Talanta, v. 259, p. 8-pg., 2023-04-14. (18/08782-1)

PATRICIO HERNANDEZ-SARAVIA, LUCAS; MARTINEZ, TAMARA; LLANOS, JAIME; BERTOTTI, MAURO. A Cu-NPG/SPE sensor for non-enzymatic and non-invasive electrochemical glucose detection. Microchemical Journal, v. 160, p. 6-pg., 2021-01-01. (18/08782-1)

ATAIDE, VANESSA NEIVA; PRADELA FILHO, LAURO ANTONIO; GUINATI, BARBARA GUERRA SOUZA; MOREIRA, NIKAELE SOUSA; GONCALVES, JULIANA DUARTE; RIBEIRO, CAMILLA MACHADO GENTIL; GRASSESCHI, DANIEL; COLTRO, WENDELL KARLOS TOMAZELLI; SALLES, MAIARA OLIVEIRA; PAIXA, THIAGO REGIS LONGO CESAR. Combining chemometrics and paper-based analytical devices for sensing: An overview. TRAC-TRENDS IN ANALYTICAL CHEMISTRY, v. 164, p. 11-pg., 2023-05-31. (18/14462-0, 18/08782-1)

DE LIMA, LUCAS F.; DE ARAUJO, WILLIAM R.. A highly efficient and portable laser-scribed graphene-based electrochemical system for forensic-oriented determination of acepromazine. ANALYTICAL METHODS, v. N/A, p. 10-pg., 2023-08-30. (22/03250-7, 18/08782-1)

Filed patent(s) as a result of this research project