Investigating dynamics on stress effect over sncRNA expression on human sperm through bioinformatic modeling

• Grant number: 23/01343-0
• Support Opportunities: Scholarships abroad - Research Internship - Doctorate (Direct)
• Start date: August 01, 2023
• End date: May 31, 2024
• Field of knowledge: Interdisciplinary Subjects
• Principal Investigator: David Corrêa Martins Junior
• Grantee: Caio Isaias da Silva Braga
• Supervisor: Tracy Lynn Bale
• Host Institution: Centro de Matemática, Computação e Cognição (CMCC). Universidade Federal do ABC (UFABC). Ministério da Educação (Brasil). Santo André , SP, Brazil
• Institution abroad: University of Colorado, Denver (CU), United States
• Associated to the scholarship: 21/00485-0 - Predicting neurodevelopment by stressors exposures through statistical models: an integrative approach, BP.DD

Abstract

Early life stress exposure is known to be associated with a change in neurodevelopment trajectories. Studies have shown an effect in a postnatal time window, through the direct child-environment interaction, but also in a prenatal setting, with the mother mediating the stress effect on the developing child. The stress effect in a preconception setting is yet understood. This study aims to investigate the scnRNA expression pattern in human sperm given stress measures changes and trauma. Understanding this dynamic could lead to a characterization of the germline's environment response and its adaptive effect on a child's development and neurodevelopment. (AU)