Niobium-functionalized bioglass and carbon fiber in critically sized bone defects in rats.

• Grant number: 23/03668-4
• Support Opportunities: Scholarships in Brazil - Scientific Initiation
• Start date: June 01, 2023
• End date: May 31, 2024
• Field of knowledge: Health Sciences - Dentistry
• Principal Investigator: Andrea Carvalho De Marco
• Grantee: Bruna Gonçalves da Silva
• Host Institution: Instituto de Ciência e Tecnologia (ICT). Universidade Estadual Paulista (UNESP). Campus de São José dos Campos. São José dos Campos , SP, Brazil

Abstract

The objective of this study is to evaluate the 45S5 mesoporous bioglass functionalized withniobium and carbon fiber in order to obtain a material with potential for synthetic bone grafting.Forty-eight adult male rats (Wistar) will be used, which will undergo a critical size bone defectin tibia, where the 4 groups, C: (blood clot), B: Bioglass 45S5, B+N: Bioglass 45S5 withmesopores functionalized with niobium and B+N+F: Bioglass 45S5 with mesoporesfunctionalized with niobium and carbon fiber; will be randomly distributed, n=6 in each group,the euthanasia periods will be 15 and 60 days. The animals will be euthanized by tripleanesthetic dose followed by decapitation. Histomorphometric and micro CT analyses will beperformed. For each analysis the data will be submitted first to descriptive statistical analysis,to establish the measures of central tendency and variability, then inferential statistics will beperformed by the ANOVA two-factor test. A conventional significance level of 5% will beadopted