Selective late-stage oxidation of C-H bonds in the synthesis of complex natural diterpenes

• Grant number: 23/03033-9
• Support Opportunities: Scholarships in Brazil - Doctorate (Direct)
• Start date: June 01, 2023
• End date: February 28, 2026
• Field of knowledge: Physical Sciences and Mathematics - Chemistry - Organic Chemistry
• Principal Investigator: Emílio Carlos de Lucca Júnior
• Grantee: Victor Camargo Stork Santana
• Host Institution: Instituto de Química (IQ). Universidade Estadual de Campinas (UNICAMP). Campinas , SP, Brazil
• Associated research grant: 18/04837-6 - Oxidation of aliphatic C-H bonds catalyzed by transition metals, AP.JP
• Associated scholarship(s): 23/11026-2 - Selective late-stage functionalization of C-H bonds in the synthesis of complex C18 oxidized diterpenes, BE.EP.DD

Abstract

One of the main challenges in the area of CH bond oxidation is the development of selective reactions due to the ubiquity of this type of bond in organic molecules and its low reactivity. In the case of catalytic systems applied at a late-stage, obtaining chemoselectivity is of great interest. In this sense, the objective of this project is to use complex natural diterpenes as platforms to perform selective C-H oxidations in the synthesis of other natural products with higher oxidative level. (AU)