assessment of the risk for thrombotic events associated with splenectomy in pacients with immune thrombocytopenia

• Grant number: 23/04157-3
• Support Opportunities: Scholarships in Brazil - Scientific Initiation
• Start date: June 01, 2023
• End date: November 30, 2024
• Field of knowledge: Health Sciences - Medicine - Medical Clinics
• Principal Investigator: Fernanda Loureiro de Andrade Orsi
• Grantee: Júlia Bertuzzo Tavares
• Host Institution: Centro de Hematologia e Hemoterapia (HEMOCENTRO). Universidade Estadual de Campinas (UNICAMP). Campinas , SP, Brazil

Abstract

SUMMARYIntroduction: The imune thrombocytopenia (ITP) is a autoimmune disorder that is characterized by the isolated low count of platelets without a alternative diagnosis. If the pacient doesn't responds or resists to the glucocorticoid treatment is necessary to perform a splenectomy. This procedure has good outcomes and a long lasting effect in its majority, however, it can lead to thrombotic and infectious events in the long term. After the splenectomy, the risk for thrombotic embolism venous in patients with ITP seens to elevate, although, without apparent reason or cause.Objectve: The objectve of this study is to assess if there is a increase of thrombotic events in pacients with ITP and who underwent the splenectomy.Materials and methods: It will be accomplished a cohort study, retrospective and multicenter, with pacients with a ITP diagnosis and that were evalueted between 2005 and 2021. It will be analysed as a closure the requency of thrombosis in ITP in pacients who did the splenectomy in comparison with the ones that didn't.

Scientific publications

(The scientific publications listed on this page originate from the Web of Science or SciELO databases. Their authors have cited FAPESP grant or fellowship project numbers awarded to Principal Investigators or Fellowship Recipients, whether or not they are among the authors. This information is collected automatically and retrieved directly from those bibliometric databases.)

SANTOS, GABRIELLE M.; DAVID, PAULA; HEN, OR; ONTIVEROS-AUSTRIA, JUAN LUIS; LIRAN, ROTEM; RODRIGUEZ-RODRIGUEZ, SERGIO; DE GODOI, JULIA CERCHIARI; PATT, YONATAN SHNEOR; BELADEV, SHAKED; OKAZAKI, ERICA; et al. Identification of phenotypes in thrombotic primary antiphospholipid syndrome using cluster analysis: a step toward personalized medicine. Journal of Thrombosis and Haemostasis, v. 23, n. 10, p. 12-pg., 2025-10-01. (23/04157-3, 22/13216-0)