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Optimization of visualization of probable epileptogenic lesion in PET/MR hybrid images with [18F]FDG PET/CT.

Grant number: 23/02888-0
Support Opportunities:Scholarships in Brazil - Scientific Initiation
Effective date (Start): July 01, 2023
Effective date (End): June 30, 2024
Field of knowledge:Health Sciences - Medicine - Medical Radiology
Principal Investigator:Lauro Wichert Ana
Grantee:Lucas Yuji Gomes Itikawa
Host Institution: Faculdade de Medicina de Ribeirão Preto (FMRP). Universidade de São Paulo (USP). Ribeirão Preto , SP, Brazil


Epilepsy is characterized by recurrent seizures, which, in most cases, can be treated with anticonvulsants. However, about a third of epilepsy cases are difficult to control with anti-seizure drugs. For these cases, surgical resection of the epileptogenic zone may result in the control of epileptic seizures. To ensure the success of a surgical intervention, the precise localization of the epileptogenic zone should be determined through electroencephalography and neuroimaging exams. OBJECTIVES: (a) Establish a protocol for processing and analyzing PET/MRI fusion images in epilepsy; (b) Investigate the contribution of PET/MRI fusion in generating lesional hypotheses in epilepsy with non-lesional 3T MRI. METHODS: Fusion images of Positron Emission Tomography (PET) [18F]FDG with Magnetic Resonance Imaging (MRI) 3T MRI of 30 patients with drug-resistant epilepsy and normal or non-specific MRI findings (non-lesional) will be processed. The PET/CTs with [18F]FDG were acquired on a GE DISCOVERYTM MI DR, 64 channel equipment. The MRIs were acquired on a PHILIPS ACHIEVA 3 Tesla equipment. The PET/MRI fusion will be performed using the Integrated Registration Module of the GE AW workstation. The quality of the fusion, it will be necessary to establish a threshold for the best general visualization, to detect partial volume artifacts, and to generate new lesional hypotheses from the PET/MRI fusion. EXPECTED RESULTS: (a) Creation of the protocol for processing and analyzing PET/MRI fusion images in epilepsy; (b) Submission of the manuscript entitled "Improved anatomical analysis in PET/MRI of epileptic patients with non-lesional 3T MRI."

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