STUDY OF THE EFFECTS OF D-LIMONENE ON GLYCEMIA IN RATS INDUCED TO DIABETES MELITTUS BY ALOXANA AND THE REPERCUSSION OF THIS TREATMENT ON THE CARDIORENAL SYSTEM AND INFLAMMATION.

• Grant number: 23/05114-6
• Support Opportunities: Scholarships in Brazil - Scientific Initiation
• Start date: August 01, 2023
• End date: January 31, 2025
• Field of knowledge: Health Sciences - Pharmacy - Pharmacognosy
• Principal Investigator: Glaucia Raquel Luciano da Veiga
• Grantee: Isabela de Paula Destro
• Host Institution: Centro Universitário FMABC (FMABC). Santo André , SP, Brazil

Abstract

Diabetes Mellitus (DM) is a metabolic syndrome of multiple origin characterized by persistent hyperglycemia or insulin resistance and resulting from lack of insulin and/or the inability of insulin to adequately exert its effects. If uncontrolled, DM can cause functional changes in different organs and systems, with emphasis on diabetic nephropathy, coronary disease, cerebrovascular disease and peripheral arterial disease. In addition to these changes, there is the presence of inflammation and increased oxidative stress, which potentiates the complications of the disease and reduces the life expectancy of diabetics. D-limonene, a monoterpene found naturally in citrus fruit peel, has demonstrated important pharmacological properties in several studies, including antioxidant, anti-inflammatory and hypoglycemic effects. Thus, the present study aims to evaluate the antidiabetic effects of D-limonene in Wistar rats induced to Diabetes Mellitus by the drug alloxan and also to investigate the possible repercussions of this treatment on the gene expression of renal (klotho, Kim-1), cardiac biomarkers (BNP) and inflammatory (IL-6).