Characterization of potential molecular targets to metabolic dysfunction induced by aminoacids restriction

• Grant number: 23/11238-0
• Support Opportunities: Scholarships in Brazil - Post-Doctoral
• Start date: October 01, 2023
• End date: July 31, 2025
• Field of knowledge: Biological Sciences - Physiology - Physiology of Organs and Systems
• Principal Investigator: Everardo Magalhães Carneiro
• Grantee: Patrícia Villela e Silva
• Host Institution: Instituto de Biologia (IB). Universidade Estadual de Campinas (UNICAMP). Campinas , SP, Brazil
• Associated research grant: 18/26080-4 - Characterization of molecular and functional mechanisms involved in endocrine-metabolic, cardiovascular and neural dysfunctions induced by the restriction of amino acids in vitro and in vivo: possible therapeutic role of bile acid TUDCA, AP.TEM

Abstract

One of the objectives of this Thematic Project is to investigate the molecular mechanisms involved on the signaling of metabolic programming induced by amino acid restriction. For that we intend to run a high performance analysis, using the technique of RNA-sequencing (RNA-seq) to elect potential candidates and test their participation on signal transduction in an amino acids restricted environment and the consequent metabolic alterations induced intracellularly.