| Grant number: | 23/11920-5 |
| Support Opportunities: | Scholarships in Brazil - Post-Doctoral |
| Start date: | October 01, 2023 |
| End date: | September 30, 2026 |
| Field of knowledge: | Interdisciplinary Subjects |
| Principal Investigator: | Maria Carolina Quartim Barbosa Elias Sabbaga |
| Grantee: | Vinicius Carius de Souza |
| Host Institution: | Instituto Butantan. Secretaria da Saúde (São Paulo - Estado). São Paulo , SP, Brazil |
| Associated research grant: | 21/11944-6 - Continuous improvement of vaccines: Center for Viral Surveillance and Serological Assessment (CeVIVAS), AP.CCD |
Abstract Viral diseases pose a continuous challenge to global public health. The CeVIVAS project has been conducting ongoing genomic surveillance of circulating Influenza and SARS-CoV-2 viruses in the State of São Paulo, the country, and neighboring countries. The data allows us to trace the evolutionary history of these viruses, understand viral variants, and assess the protective capacity of available vaccines for the population. The integration of experimental science with computational tools represents an innovative approach for addressing viral diseases. The comprehension of molecular interactions between antibodies and viruses, coupled with the utilization of computational methods, provides a promising outlook for the development of more effective and accessible therapies in the field of viral immunotherapy, making significant contributions to global public health. Monoclonal antibodies have emerged as a potent therapeutic strategy, with scFv/Fab antibody fragments gaining prominence due to their high specificity and versatility. In this context, the current study aims to employ computational methods to (i) identify human-produced Complementarity-Determining Regions (CDRs) in response to viral infection/vaccination; (ii) assess the interaction of identified CDRs with the structures of antigenic proteins from circulating viral strains (detected through genomic surveillance established in the CeVIVAS project); (iii) predict and structurally optimize scFv/Fab antibodies based on data obtained from objectives (i) and (ii), with the goal of advancing the treatment of diseases caused by the viruses under study in the project. | |
| News published in Agência FAPESP Newsletter about the scholarship: | |
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