Low frequency sound waves to form Nevirapine co-crystals

• Grant number: 23/08683-1
• Support Opportunities: Scholarships in Brazil - Scientific Initiation
• Start date: December 01, 2023
• End date: February 14, 2026
• Field of knowledge: Engineering - Chemical Engineering - Chemical Technology
• Principal Investigator: Eduardo Rezende Triboni
• Grantee: Gabriela Kaori Taneguti Ueno
• Host Institution: Escola de Engenharia de Lorena (EEL). Universidade de São Paulo (USP). Lorena , SP, Brazil
• Associated scholarship(s): 25/04314-7 - Crystallization of Paracetamol in Eutectic Molecular Solvent, BE.EP.IC

Abstract

The present proposal intends to study the synthesis of Nevirapine co-crystals under the influence of a low frequency acoustic field. This unprecedented experimentation will involve crystallization under acoustic amplitude (dB) and different frequencies (between 30 Hz and 100 Hz). For the co-crystallization the co-formers caffeine, benzoic acid, 3-hydroxy-benzoic acid, and 4-hydroxy-benzoic acid will be used. The characterization of the co-crysts will be done by X-Ray Diffraction, calorimetry and infrared and Raman spectroscopy. The materials will be compared with those obtained from other crystallization techniques.