Local delivery of Genistein associated with Biogran® in the filling of peri-implant bone defects: pre-clinical study in ovariectomized rats.

• Grant number: 23/05814-8
• Support Opportunities: Scholarships in Brazil - Scientific Initiation
• Start date: November 01, 2023
• End date: October 31, 2025
• Field of knowledge: Health Sciences - Dentistry - Oral and Maxillofacial Surgery
• Principal Investigator: Roberta Okamoto
• Grantee: Marcelly Braga Gomes
• Host Institution: Faculdade de Odontologia (FOA). Universidade Estadual Paulista (UNESP). Campus de Araçatuba. Araçatuba , SP, Brazil

Abstract

Biomaterials are fundamental and innovative role in Dentistry, mostly in Oral Rehabilitation, due to the search for an ideal bone substitute. Although the performance of some of thesebiomaterialsis satisfactory with good osteoconductive properties, there isessentialto improve these products, which can be done through the addition of biomolecules that can improve their properties and optimize bone repair. The purpose of this project will be to evaluate, through biomechanical and microtomographic analysis, the benefits of Biogran®, in the process of bone repair in peri-implant defects, in ovariectomized rats. For this study, 40 randomized and ovariectomized female rats will be divided into 4 groups: OVX CLOT (negative control - clot),OVX BG (Biogran® in natura), OVX BGS (Biogran® sonicated), OVX BGS+GEN (Biogran® sonicated with genistein). A bilateral peri-implant defect will be made in the tibial metaphysis of the animals. After 28 days of installation of the implants, euthanasia and analyzes will be performed. The data will be submitted to a normality curve to determine the appropriate statistical test in the GraphPad Prism 7.03 software, adopting a significance level of P < 0.05.

Scientific publications

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

DUARTE, NATHALIA DANTAS; MULINARI-SANTOS, GABRIEL; BATISTA, FABIO ROBERTO DE SOUZA; GOMES, MARCELLY BRAGA; MONTEIRO, NAARA GABRIELA; DA SILVA, ANA CLAUDIA ERVOLINO; GRUBER, REINHARD; LISBOA-FILHO, PAULO NORONHA; GOMES-FERREIRA, PEDRO HENRIQUE SILVA; OKAMOTO, ROBERTA. Sonification of Deproteinized Bovine Bone Functionalized with Genistein Enhances Bone Repair in Peri-Implant Bone Defects in Ovariectomized Rats. JOURNAL OF FUNCTIONAL BIOMATERIALS, v. 15, n. 11, p. 12-pg., 2024-11-01. (22/07158-8, 23/05814-8)