Investigation of the potential neuroprotective effect of the monoterpene 1,8 cineole complexed in beta-cyclodextrin in an animal model of reserpine-induced Parkinson's disease.

• Grant number: 23/11947-0
• Support Opportunities: Scholarships in Brazil - Scientific Initiation
• Start date: November 01, 2023
• End date: May 31, 2024
• Field of knowledge: Biological Sciences - Pharmacology - Neuropsychopharmacology
• Principal Investigator: Alessandra Mussi Ribeiro
• Grantee: Luan Araújo Monteiro
• Host Institution: Instituto de Saúde e Sociedade (ISS). Universidade Federal de São Paulo (UNIFESP). Campus Baixada Santista. Santos , SP, Brazil

Abstract

The use of natural products as therapeutic resources has been documented for thousands of years. Isolated compounds from plant extracts may have different therapeutic characteristics acting on different physiological systems, such as the central nervous system. The number of individuals affected by neurodegenerative diseases has increased significantly in recent decades. Parkinson's disease (PD) is the second degenerative disease and its progression is not controlled by available drugs. The treatment with levodopa (L-DOPA), the first drug choice, has limited beneficial effects and unpleasant adverse effects. Thus, the development of novel drugs to help in the control of the symptoms and progression of PD is unquestionable. Terpenes are an important class of substances isolated from natural sources with different therapeutic activities. The 1,8-cineole monoterpene, is a substance found in several plant extracts including eucalyptus, previous studies have demonstrated that 1,8-cineole has neuroprotective, antioxidant, anti-inflammatory, and anti-apoptotic effects. In addition, when these essential oils were complexed or encapsulated on cyclodextrin (host), presented an improvement in the bioavailability and pharmacological effects. Therefore, this study aims to investigate the potential neuroprotective effect of 1,8 cineole in a progressive animal model of Parkinson's disease in mice.