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Genetic modification of Dunaliella salina for the production of beta-carotene

Grant number: 23/09238-1
Support Opportunities:Scholarships abroad - Research Internship - Doctorate
Start date: March 15, 2024
End date: March 14, 2025
Field of knowledge:Agronomical Sciences - Food Science and Technology - Food Science
Principal Investigator:João Carlos Monteiro de Carvalho
Grantee:Évellin do Espírito Santo
Supervisor: Stephen Mayfield
Host Institution: Faculdade de Ciências Farmacêuticas (FCF). Universidade de São Paulo (USP). São Paulo , SP, Brazil
Institution abroad: University of California, San Diego (UC San Diego), United States  
Associated to the scholarship:22/07026-4 - Genetic modification in the production of betacarotene by Dunaliella salina, BP.DR

Abstract

Microalgae arouse technological and industrial interest, as they produce components of high added value, being fully used in the form of extracts, or purified compounds, in food, pharmaceutical and cosmetic formulations, among others. Dunaliella salina is the main carotenoid-producing microalgae. Obtaining biomass with higher levels of carotenoids reduces the cost of production, as there is a need to process a smaller amount of biomass to obtain the pigments. This microalgae is promising in the field of genetic engineering. Therefore, the objective of this project is to knock out the gene that encodes the enzyme lycopene e-cyclase in the chloroplast genome using the CRISPR/CAS9 technique.

News published in Agência FAPESP Newsletter about the scholarship:
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