Characterization of the clinical profile of normotensive and preeclamptic patients for the study of the relationship between endocrine disruptors and preeclampsia

• Grant number: 23/12666-5
• Support Opportunities: Scholarships in Brazil - Scientific Initiation
• Start date: January 01, 2024
• End date: December 31, 2025
• Field of knowledge: Health Sciences - Medicine - Maternal and Child Health
• Principal Investigator: Arielle Cristina Arena
• Grantee: Sara Tawany Caetano dos Santos
• Host Institution: Instituto de Biociências (IBB). Universidade Estadual Paulista (UNESP). Campus de Botucatu. Botucatu , SP, Brazil
• Associated research grant: 21/12010-7 - Endothelial dysfunction in hypertensive disorders of pregnancy, AP.TEM

Abstract

It is likely that the Endothelial Dysfunction (ED) found in Hypertensive Disorders of Pregnancy (HDP) are evoked by the actions of multiple factors and several pathways. Then the discovery and the understanding of these converging pathways that contribute to ED and poor outcome of pregnancy can addressing potential molecules with are modulated by different drugs. The use of omics tools, such as transcriptome and proteome, may help in this field. Importantly although the knowledge of ED in HDP and the mechanisms underlying these processes are now becoming increasingly understood, this is not corresponding to developments in drug development/uses. There are no investments of pharmacy industries in this field due probably to high-risk investment in pregnant treatment. Moreover, even with improvement in researches on the pathophysiology of gestational hypertensive diseases, drug therapy remains limited and, therefore, is a contributing factor to the maintenance of high rates of maternal mortality. Therefore the current proposal will explore ED in HDP. We have divided it into five subprojects: SP1 - Endothelial dysfunction in pre-eclampsia: potential drugs and new pharmacological targets obtained from "omics" tools SP2 - Blood pressure control in chronic hypertensive pregnant women with beetroot juice supplementation starting in the 2nd trimester (BEET_CH) SP3 - Evaluation of endothelial dysfunction in experimental model of preeclampsia-like symptoms induced by reduction of uterine perfusion pressure (RUPP) in pregnant rats SP 4- Study of endocrine disruptors and sex hormones in PE (EDRs) SP 5 - Biomarkers and pharmacogenetics of antihypertensive therapy in preeclampsia.