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Relationship between biomarkers and cardiac morphofunctional changes in the differentiation between early-onset and late-onset pre-eclampsia


Objective: To evaluate the blood biomarkers in pregnant women with early- and late-onset preeclampsia and their association with cardiac morphofunctional changes. Subjects and methods: A prospective study in pregnant women who will receive prenatal and/or delivery care in the Obstetric Unit of Botucatu Medical School, UNESP, Botucatu, SP, Brazil. At diagnosis, pregnant women will be stratified according to gestational age into two groups: early-onset pre-eclampsia (<34 weeks) and late-onset pre-eclampsia (e34 weeks). The control group will be formed by normotensive pregnant women without disease and matched for gestational age with preeclamptic patients. Blood samples will be collected for determination of biomarkers (C-reactive protein, brain natriuretic peptide and cytokines: TNF-alpha IL-1beta, IL-6, IL-10, TGF-beta1). Maternal echocardiography examination will be performed in both normotensive and preeclamptic women. The calculation of sample size was set at 28 women per group. The results will be statistically analyzed and differences between groups will set at p <0.05. Expected results: The study will allow better understand of the preeclampsia pathophysiology, as well as to improve methods of identifying the different manifestations of the disease in its early and late stages. The results may permit to establish different strategies for prevention and pharmacological treatment of the preeclampsia. (AU)

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