Assessment of the incidence and severity of COVID-19 among recently transplanted and previously vaccinated within a period of 12 months.

• Grant number: 23/17870-0
• Support Opportunities: Scholarships in Brazil - Scientific Initiation
• Start date: February 01, 2024
• End date: January 31, 2025
• Field of knowledge: Health Sciences - Medicine - Medical Clinics
• Principal Investigator: Jose Osmar Medina de Abreu Pestana
• Grantee: Julia Soares Reis
• Host Institution: Escola Paulista de Medicina (EPM). Universidade Federal de São Paulo (UNIFESP). Campus São Paulo. São Paulo , SP, Brazil
• Associated research grant: 21/13680-6 - Evaluation of SARS-CoV-2 infection and Coronavirus vaccine response in transplant recipients, dialysis patients, and health workers, AP.TEM

Abstract

Patients with chronic renal failure on dialysis respond humoral to coronavirus vaccination schedules superior to kidney transplant recipients. It is possible that immunosuppressive medications interfere with the robustness and durability of the responseimmunological. Furthermore, a Chilean study with real-life data, involving more than 50 thousandindividuals, suggested that the durability of the response is influenced by the type of vaccine used, as note that IgG seropositivity was lower after vaccination with CoronaVac versus Pfizer (77.4% versus 96.5%) and declined over time since vaccination with CoronaVac, but not with Pfizer.