Scholarship 24/02402-3 - Caracteres sexuais, Esquizofrenia - BV FAPESP
Advanced search
Start date
Betweenand
Related content

BEHAVIORAL AND NEUROCHEMICAL EFFECTS OF THE CANNABINOID CANNABIGEROL IN AN ANIMAL MODEL OF SCHIZOPHRENIA

Grant number: 24/02402-3
Support Opportunities:Scholarships in Brazil - Scientific Initiation
Start date until: May 01, 2024
End date until: December 31, 2024
Field of knowledge:Biological Sciences - Pharmacology - Neuropsychopharmacology
Principal Investigator:Vanessa Costhek Abílio
Grantee:Beatriz dos Santos Correa
Host Institution: Escola Paulista de Medicina (EPM). Universidade Federal de São Paulo (UNIFESP). Campus São Paulo. São Paulo , SP, Brazil

Abstract

Schizophrenia is a debilitating mental disorder that affects 0.29% of the world's population. Despite having medications aimed at treating the symptoms of schizophrenia, such drugs induce serious adverse effects and are only effective in treating the positive symptoms of the disorder. For this reason, new therapeutic alternatives have been studied, with our group focusing on cannabinoid compounds. Cannabigerol (CBG), a bioactive compound found in Cannabis sativa, has effects similar to CBD, such as antioxidant, anti-inflammatory, and neuromodulatory effects. Thus, considering previous studies that point to a therapeutic and preventive effect of CBD regarding the onset of behaviors associated with schizophrenia symptoms, the aim of this project is to characterize the behavioral effects induced by the administration of CBG in an animal model of NMDA receptor antagonism in adult mice. For this, female and male C57BL/6J mice will undergo two experiments. In experiment 1, mice will receive an acute dose of CBG (1, 5, or 10 mg/kg, i.p.) followed by an MK-801 challenge (0.5 mg/kg, i.p.). In experiment 2, mice will receive CBG for 15 days (dose to be defined according to experiment 1), and MK-801 (0.5 mg/kg, i.p.) concomitantly during the last seven days of CBG treatment. After the completion of acute or chronic treatments, all animals will undergo behavioral evaluations through spontaneous alternation, open field locomotor activity, social interaction, and prepulse inhibition (PPI) tests. They will then be euthanized for quantification of oxidative stress parameters (lipid peroxidation) and neuroinflammation (pro- and anti-inflammatory cytokines).

News published in Agência FAPESP Newsletter about the scholarship:
More itemsLess items
Articles published in other media outlets ( ):
More itemsLess items
VEICULO: TITULO (DATA)
VEICULO: TITULO (DATA)

Please report errors in scientific publications list using this form.