Rheumatoid Arthritis and subclinical Atherosclerosis: cross-sectional and prospective results of the Longitudinal Study of Adult Health (ELSA-Brazil)

• Grant number: 24/04191-0
• Support Opportunities: Scholarships in Brazil - Doctorate (Direct)
• Start date: May 01, 2024
• End date: October 31, 2025
• Field of knowledge: Health Sciences - Collective Health - Epidemiology
• Principal Investigator: Isabela Judith Martins Bensenor
• Grantee: Patrícia Fonseca Estrada
• Host Institution: Hospital Universitário (HU). Universidade de São Paulo (USP). São Paulo , SP, Brazil
• Associated research grant: 19/23734-6 - Chronic inflammatory diseases and all-cause, cardiovascular and mortality related to other causes: association with risk factors, subclinical Atherosclerosis and fatal and non-fatal events in the Brazilian Longitudinal Study of Adult Health (ELSA-Brasil), AP.TEM

Abstract

Studies suggest that inflammatory diseases (ID) such as rheumatoid arthritis (RA)would associate the presence of subclinical atherosclerosis and cardiovascular disease (CVD). OELSA-Brasil is a prospective cohort study that includes the study of risk factorsclassic and non-classical for CVD and their relationship with the incidence of CVD and diabetes.The objective of this project is to evaluate the incidence of subclinical atherosclerosis measured bycalcium score (CAC) in participants who reported the presence of RA in thebaseline or follow-up. The identification of the presence of AR would be done by asking questions aboutmedical diagnosis of diseases, use of medications and the presence of biomarkersassociates dosed from biological samples stored at -180 o C collected in 2008-2010 (baseline) with 9-year follow-up: rheumatoid factor and anti-CCP. Youresults will be presented by logistic regression (cross-sectional data) and regressionPoisson with unadjusted relative risk calculation, adjusted for factorssociodemographic and with multivariate adjustment for confounding factors. (AU)