Linear Free Energy Relationships in Diels-Alder Aminocatalysed Reactions

• Grant number: 24/09518-7
• Support Opportunities: Scholarships in Brazil - Scientific Initiation
• Start date: July 01, 2024
• End date: June 30, 2025
• Field of knowledge: Physical Sciences and Mathematics - Chemistry - Organic Chemistry
• Principal Investigator: Bruno Matos Paz
• Grantee: Julia Yumi Fontes Jamatto
• Host Institution: Instituto de Química (IQ). Universidade de São Paulo (USP). São Paulo , SP, Brazil
• Associated research grant: 22/14310-0 - Linear free energy relationships in asymmetric catalysis, AP.JP

Abstract

Competition experiments in Diels-Alder reactions using dienes and dienophiles containing aromatic rings substituted in four different positions will be performed using iminium-ion catalysis. The ratio between the products will provide the desired Linear Free Energy Relationshops (LFER), one of the first examples of such an application to asymmetric organocatalysis. The LFER obtained here will be correlated with the endo/exo and the enantiomeric ratios.