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Synthesis and application of organocatalysts in asymmetric epoxidation reactions in order to synthesis of pheromones

Grant number: 10/07664-3
Support type:Scholarships in Brazil - Doctorate
Effective date (Start): July 01, 2010
Effective date (End): February 28, 2013
Field of knowledge:Physical Sciences and Mathematics - Chemistry
Principal Investigator:Arlene Gonçalves Corrêa
Grantee:Anna Maria Deobald
Home Institution: Centro de Ciências Exatas e de Tecnologia (CCET). Universidade Federal de São Carlos (UFSCAR). São Carlos , SP, Brazil
Associated research grant:09/07281-0 - Asymmetric organocatalysis: design of new organocatalysts and development of new methodologies, AP.JP

Abstract

Given the importance that currently occupies the organocatálise in the world scene and the gap in the development of new organocatalisadores and the discovery of new methodologies, the objective is to prepare new organocatalisadores that can be used in different classes of enantioselective reactions. These will be synthesized using organocatalisadores platforms such as chiral compounds obtained enantiomeric pure in its form, from natural sources such as sugars, amino acids and steroids. Possession of this new collection of organocatalisadores plan is to use them as agentsresponsible for the transfer of chirality in epoxidation reactions (olefin rich and deficient in electrons) under conditions that conform to the principles of Green Chemistry (absence of metals, organic solvents and anhydrous conditions).Additionally, the objective is the application of the developed catalysts for the synthesis of isolated and studied pheromone to assess the biological potential each stereoisomer.