Correlation of ACR BI-RADS® descriptors on Magnetic Resonance Imaging with breast carcinoma patient survival

• Grant number: 24/04897-0
• Support Opportunities: Scholarships in Brazil - Scientific Initiation
• Start date: July 01, 2024
• End date: June 30, 2025
• Field of knowledge: Health Sciences - Medicine - Medical Radiology
• Principal Investigator: Eduardo Carvalho Pessoa
• Grantee: Douglas Luciano Moura Filho
• Host Institution: Faculdade de Medicina (FMB). Universidade Estadual Paulista (UNESP). Campus de Botucatu. Botucatu , SP, Brazil

Abstract

Breast cancer represents the most prevalent neoplasm among women globally, affecting individuals in both developing and developed countries. According to the International Agency for Research on Cancer (IARC) in 2020, more than 2.3 million cases of breast cancer were diagnosed, surpassing lung cancer cases and currently being the most prevalent type of cancer, accounting for 11.7% of the total - the highest impact on people at a global level. In addition to its high incidence, breast cancer is also the leading cause of cancer death among women, corresponding to 15.5% of cancer deaths with an estimated 684,996 deaths in the year 2020. In Brazil, the National Cancer Institute (INCA) predicts that there will be 73,610 new cases of breast cancer annually during the triennium of 2023-2025.Breast carcinomas constitute a heterogeneous group of diseases, exhibiting diverse biological behaviors and therapeutic responses. Against this backdrop, various research sectors are dedicated to identifying prognostic predictors for these tumors. One of these sectors is breast imaging, which, under the concept of radiogenomics - that is, the correlation between imaging features of breast lesions and their biological behavior - has been exploring the association of imaging predictors with biomolecular markers, yielding promising results. This approach aims to estimate prognosis and guide treatment, offering a minimally invasive and relatively accessible method compared to molecular signatures. However, the literature contains limited data correlating imaging descriptors, particularly from Breast Magnetic Resonance Imaging (MRI), with patient survival.In this context, our study is pioneering, aiming to correlate the imaging descriptors of breast carcinomas from ACR BI-RADS® in MRI with the survival of patients with this disease. We will conduct a retrospective cohort observational study of patients with breast carcinomas treated at the Hospital das Clínicas de Botucatu - UNESP, during the period from 2014 to 2022.