Validation of the microscale synthesis platform.

• Grant number: 24/09350-9
• Support Opportunities: Scholarships in Brazil - Scientific Initiation
• Start date: July 01, 2024
• End date: June 30, 2025
• Field of knowledge: Physical Sciences and Mathematics - Chemistry - Organic Chemistry
• Principal Investigator: Daniel Gedder Silva
• Grantee: Nathalia Alves de Aguilar
• Host Institution: Faculdade de Ciências Farmacêuticas de Ribeirão Preto (FCFRP). Universidade de São Paulo (USP). Ribeirão Preto , SP, Brazil
• Associated research grant: 23/11804-5 - Combining Microscale Parallel Synthesis (MPS) and Medium-Throughput Screening (MTS) for Accelerated Hit-to-lead Optimization of Anti-Infective Agents., AP.JP

Abstract

The Microscale Parallel Synthesis (MPS) method combined with the screening of unpurified compounds in parasite-infected cells needs to be validated using traditional synthesis. To test whether raw material from reactions can provide useful screening results against parasite panel assays, the most promising compounds identified will be resynthesized, purified and characterized. Thus, the undergraduate research project will support the main Fapesp Young Investigator Grant (2023/11804-5). The student will assist master's and doctoral students in the traditional synthesis of identified products. For example, to implement the MPS platform and apply the advantages of this method in other projects, the influence of the urea moiety on the basic structure of imidazopyrimidine-derived compounds will initially be explored. The core rings (starting materials) need to be traditionally synthesized and purified. Subsequently, after applying the MPS method, the compounds identified as promising will also be synthesized and purified.