Duo-gasotransmitters for biomedical applications: bioformulation of nanoparticles containing Aspirin-NOSH

• Grant number: 23/16363-7
• Support Opportunities: Scholarships in Brazil - Post-Doctoral
• Start date: August 01, 2024
• End date: July 31, 2026
• Field of knowledge: Physical Sciences and Mathematics - Chemistry - Physical-Chemistry
• Principal Investigator: Amedea Barozzi Seabra
• Grantee: Roberta Albino dos Reis
• Host Institution: Centro de Ciências Naturais e Humanas (CCNH). Universidade Federal do ABC (UFABC). Ministério da Educação (Brasil). Santo André , SP, Brazil
• Associated research grant: 22/14645-2 - Nitric oxide releasing hydrogels and vascular prosthesis for cardiovascular applications, AP.TEM

Abstract

Nitric oxide (NO) and hydrogen sulfide (H2S) are endogenous molecules and gaseous transmitters of great relevance in several physiological and pathophysiological processes. Both molecules, depending on their concentrations and the cellular environment where they are found, can have anti-inflammatory, antioxidant, pro-apoptotic, cytoprotective and antimicrobial actions. Recent studies suggest a connection between the mechanisms of action of these two molecules. Due to the impact of H2S and NO on the biological environment, there is great interest in incorporating these molecules into non-toxic polymeric matrices capable of promoting the sustained and localized release of these gaseous transmitters at the target of interest. Despite the recent and intense interest of the Scientific Community, there are still several gaps regarding the mechanism(s) of interaction between NO and H2S in biological systems, in different conditions, locations and concentrations. In this context, this project focuses on the development of NO and/or H2S releasing systems, based on nanoparticles, and their impacts on cell cultures focusing on combined actions. In particular, the toxicity of the materials developed in this project will be explored in the culture of tumor and non-tumor cells, in the inflammatory response and in oxidative stress. The project involves concepts of chemistry, biology and nanomaterials, and will allow scientific and technological development in the development of nanomaterials that release gaseous transmitters and their impact on the biological system. The project also includes the request for a BEPE internship in Prof. Dr Khosrow Kashfi of the University of New York School of Medicine (Department of Molecular, Cellular and Biomedical Sciences), president of the International Society for Nitric Oxide and Cancer.

Scientific publications

(4)

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

TORTELLA FUENTES, GONZALO; FINCHEIRA, PAOLA; RUBILAR, OLGA; LEIVA, SEBASTIAN; FERNANDEZ, IVETTE; SCHOEBITZ, MAURICIO; PELEGRINO, MILENA T.; PAGANOTTI, ANDRE; DOS REIS, ROBERTA ALBINO; SEABRA, AMEDEA B.. Nanoparticle-Based Nitric Oxide Donors: Exploring Their Antimicrobial and Anti-Biofilm Capabilities. ANTIBIOTICS-BASEL, v. 13, n. 11, p. 22-pg., 2024-11-01. (22/14645-2, 23/16363-7, 23/12466-6)

NUNES, RENAN S.; MARIANO, KELLI C. FREITAS; PIERETTI, JOANA C.; DOS REIS, ROBERTA A.; SEABRA, AMEDEA B.. Innovative nitric oxide-releasing nanomaterials: Current progress, trends, challenges, and perspectives in cardiovascular therapies. NITRIC OXIDE-BIOLOGY AND CHEMISTRY, v. 156, p. 15-pg., 2025-06-01. (24/12112-2, 22/14645-2, 23/16363-7, 24/04079-5, 20/03646-2)

DOS REIS, ROBERTA ALBINO; SARKAR, ISHANI; RODRIGUES, MAIARA GONCALVES; MATSON, JOHN B.; SEABRA, AMEDEA BAROZZI; KASHFI, KHOSROW. NO- and H2S-releasing nanomaterials: A crosstalk signaling pathway in cancer. NITRIC OXIDE-BIOLOGY AND CHEMISTRY, v. 151, p. 14-pg., 2024-09-05. (22/00321-0, 22/14645-2, 23/16363-7)

PREISLER, ANA CRISTINA; DO CARMO, GIOVANNA CAMARGO; DA SILVA, RAFAEL CAETANO; SIMOES, ANA LUISA DE OLIVEIRA; IZIDORO, JULIANA DE CARVALHO; PIERETTI, JOANA CLAUDIO; DOS REIS, ROBERTA ALBINO; JACOB, ANDRE LUIZ FLORIANO; SEABRA, AMEDEA BAROZZI; OLIVEIRA, HALLEY CAIXETA. Improving Soybean Germination and Nodule Development with Nitric Oxide-Releasing Polymeric Nanoparticles. PLANTS-BASEL, v. 14, n. 1, p. 19-pg., 2025-01-01. (24/12112-2, 20/03646-2, 23/16363-7, 22/03914-2)