Therapeutic, pharmacokinetic and pharmacodynamic profile of the oligopeptides derived from the snake venom B. Jararaca in the Parkinson's disease model in Zebrafish

• Grant number: 24/10831-1
• Support Opportunities: Scholarships in Brazil - Support Program for Fixating Young Doctors
• Start date: July 01, 2024
• End date: June 30, 2025
• Field of knowledge: Biological Sciences - Pharmacology - Biochemical and Molecular Pharmacology
• Agreement: CNPq
• Principal Investigator: Carlos Alberto da Silva
• Grantee: Adolfo Luis Almeida Maleski
• Host Institution: Centro de Ciências Naturais e Humanas (CCNH). Universidade Federal do ABC (UFABC). Ministério da Educação (Brasil). Santo André , SP, Brazil
• Associated research grant: 24/02247-8 - Therapeutic, pharmacokinetic and pharmacodynamic profile of the oligopeptides derived from the snake venom B. Jararaca in the Parkinson's disease model in Zebrafish, AP.R

Abstract

Neuroprotection mediated by proline-rich oligopeptides (PROs), derived from Bothrops jararaca snake venom, has been reported when different neuronal cell cultures are pre-treated with PROs and then exposed to oxidative stress. The neuroprotection of PRO-10c (