Bone scaffolds based on starch hydrogels activated by the presence of nanoparticles of hydroxyapatite functionalized with cobalt and gallium osteinductive ions

• Grant number: 24/13627-6
• Support Opportunities: Scholarships in Brazil - Scientific Initiation
• Start date: September 01, 2024
• End date: August 31, 2025
• Field of knowledge: Physical Sciences and Mathematics - Chemistry - Physical-Chemistry
• Principal Investigator: Bianca Chieregato Maniglia
• Grantee: Fernanda Corrêa de Nóbrega
• Host Institution: Instituto de Química de São Carlos (IQSC). Universidade de São Paulo (USP). São Carlos , SP, Brazil
• Associated research grant: 20/08727-0 - Starch modification by green methods for elaboration via 3D printing of bone scaffolds activated by the presence of hydroxyapatite nanoparticles replaced by Sr2+, AP.JP

Abstract

3D printing of bone scaffolds produced from starch gels and hydroxyapatite nanoparticles has been reported in the literature. Despite showing structural similarity to biological apatite, synthetic hydroxyapatite does not present its bioactivity, since biological apatite presents trace elements that play a key role in the bone remodeling process. More specifically, nanoparticles of hydroxyapatite doped with cobalt and gallium ions have been associated with regulating bone formation and resorption processes. Therefore, this project aims to evaluate the effect of these ions in hydroxyapatite nanoparticles on the functional and active properties of bone scaffolds (based on starch gels) produced via 3D printing. The properties evaluated will be mechanical, swelling, biodegradability, in vitro bioactivity, cell viability, mineralization capacity, and evaluation of ion release. Finally, this study will make it possible to understand how much cobalt and gallium ions can cooperate in the properties of bone scaffolds based on starch gels produced via 3D printing.