Validation and supervision of in house synthesis methodology for the application of the radiopharmaceutical FAPI for theranostic of neoplasms

• Grant number: 24/15854-0
• Support Opportunities: Scholarships in Brazil - Post-Doctoral
• Start date: October 01, 2024
• End date: September 30, 2026
• Field of knowledge: Health Sciences - Medicine - Medical Radiology
• Principal Investigator: Elba Cristina Sá de Camargo Etchebehere
• Grantee: Ellen Nogueira Lima
• Host Institution: Centro de Hematologia e Hemoterapia (HEMOCENTRO). Universidade Estadual de Campinas (UNICAMP). Campinas , SP, Brazil
• Associated research grant: 21/10265-8 - Cancer Theranostics Innovation Center (CancerThera), AP.CEPID

Abstract

The main objective of this research is to perform and supervise radiopharmacy studies related to developing the in house labeling of the fibroblast activation protein (FAPI) molecule first with gallium-68 and then with lutetium-177 for FAPITher for theranostic.This process will include the validation of the synthesis process and quality control of the final product and the evaluation of the stability of radiolabeled elements and other parameters. This labeling will be performed in agreement with the standard guidelines and international pharmacopeia.