Effect of pH on binary and ternary systems formed from the self-aggregation of bile salts in the presence of nanocellulose

• Grant number: 24/00827-7
• Support Opportunities: Scholarships in Brazil - Master
• Start date: November 01, 2024
• End date: January 31, 2026
• Field of knowledge: Physical Sciences and Mathematics - Chemistry - Physical-Chemistry
• Principal Investigator: Kelly Roberta Francisco Muruci de Paula
• Grantee: Vinícius Augusto Peixoto Tartare
• Host Institution: Centro de Ciências Agrárias (CCA). Universidade Federal de São Carlos (UFSCAR). Araras , SP, Brazil

Abstract

This master's project consists of evaluating the influence of pH variation on binary and ternary self-aggregated systems of bile salts, which form spontaneously in an aqueous medium, modulated by the presence of nanocellulose, as well as their application as platforms for the controlled release of lidocaine . The structure of these aggregates can be modified depending on the molecules that are dispersed in the medium, such as nanocellulose. Furthermore, the morphology of self-aggregates can also undergo changes depending on variations in the pH of the medium. As a consequence of these morphological changes, the rheological behavior of these systems will be directly altered. With this in mind, this proposed master's project seeks to evaluate the effects of pH change on binary and ternary self-aggregates of bile salts (sodium taurodeoxycholate, sodium deoxycholate and sodium cholate), formed spontaneously in an aqueous medium, in presence of cellulose nanocrystals (CNCs) and cellulose nanofibrils (CNFs), in addition to evaluating the systems as potential anesthetic releasers. Rheology, dynamic light scattering (DLS) and low-angle X-ray (SAXS) techniques will be used to provide structural information on these aggregates in solution, such as their viscosities, sizes and particle distribution. . Furthermore, zeta potential (PZ) analyzes will be necessary to evaluate the colloidal stability of the systems. Carrying out this research seeks to understand the interactions established between the system-forming components, depending on the pH of the medium, so that their rheological properties are explained in a correlated way with their aggregations, size distributions, colloidal stabilities, as well as morphologies. of these aggregates, enabling the consolidation of systems as drug release platforms.