Effect of chemical modified heparins in the conformation and biological activity of antithrombin

• Grant number: 24/18192-8
• Support Opportunities: Scholarships in Brazil - Program to Stimulate Scientific Vocations
• Start date: January 06, 2025
• End date: February 20, 2025
• Field of knowledge: Biological Sciences - Biochemistry - Chemistry of Macromolecules
• Principal Investigator: Helena Bonciani Nader
• Grantee: João Oliveira Sampaio
• Host Institution: Escola Paulista de Medicina (EPM). Universidade Federal de São Paulo (UNIFESP). Campus São Paulo. São Paulo , SP, Brazil

Abstract

The project seeks to understand how heparin interacts with antithrombin, a key protein in the coagulation process, and how this interaction affects antithrombin's ability to inhibit angiogenic processes, such as the formation of new blood vessels. Studies suggest that chemical modification of heparin can alter antithrombin's antiangiogenic activity, pointing to a potential therapeutic approach to regulate angiogenesis in pathological conditions.