Intramolecular Nucleophilic Aromatic Substitution Mechanisms in Fluorophenols: A Detailed Study

• Grant number: 24/22123-1
• Support Opportunities: Scholarships in Brazil - Scientific Initiation
• Start date: February 01, 2025
• End date: January 31, 2026
• Field of knowledge: Physical Sciences and Mathematics - Chemistry - Organic Chemistry
• Principal Investigator: Claudio Francisco Tormena
• Grantee: Murilo Lucass Alves
• Host Institution: Instituto de Química (IQ). Universidade Estadual de Campinas (UNICAMP). Campinas , SP, Brazil
• Associated research grant: 20/10246-0 - Nuclear magnetic resonance spectroscopy: from pulse sequences to structural assignments, AP.TEM

Abstract

This study explores the intramolecular coupling of various ortho-fluorophenols with cyclohexene oxide via one-pot methodology under basic conditions. Optimization includes tests with different bases, solvents and temperatures. Reaction products will be characterized experimentally, and theoretical analysis are aimed to identify the most favourable mechanistic pathway.