Development of synthetic methodologies for the synthesis and vectorial functionalization of 5,8-dihydro-1,6-naphthyridin-7(6H)-one: An approach involving FBDD.

• Grant number: 24/22760-1
• Support Opportunities: Scholarships in Brazil - Master
• Start date: May 01, 2025
• End date: September 30, 2026
• Field of knowledge: Physical Sciences and Mathematics - Chemistry - Organic Chemistry
• Principal Investigator: Giuliano Cesar Clososki
• Grantee: Guilherme Batista Simoso
• Host Institution: Faculdade de Ciências Farmacêuticas de Ribeirão Preto (FCFRP). Universidade de São Paulo (USP). Ribeirão Preto , SP, Brazil

Abstract

In this research project, we aim to apply the innovative and promising strategy of fragment-based drug discovery (FBDD), an approach that employs small molecules, known as fragments, to identify and optimize interactions with therapeutic targets. The primary focus will be on the fragment 5,8-dihydro-1,6-naphthyridin-7(6H)-one, aligned with the advancements of the team at Durham University, identified through their heterocyclic fragment library (ROF2). The synthesis of this fragment will be conducted using an already validated methodology, with the potential for optimization to enhance efficiency and reduce the complexity of the reaction steps. Vectorial functionalization will be explored through metalation and radical reactions, alongside the integration of enabling technologies such as continuous flow, photocatalysis, and electrochemistry, which may expand the diversity of the methodologies. Additionally, we aim to consolidate our research group's expertise in the functionalization of heteroaromatics, emphasizing the generation of novel drug candidates by leveraging the innovative methodologies and advanced technologies developed over the years.