Evaluation of the models Flory-Huggins and PC-SAFT in the prediction of solubility and miscibility in amorphous solid dispersions

• Grant number: 25/02478-2
• Support Opportunities: Scholarships abroad - Research Internship - Scientific Initiation
• Start date: May 28, 2025
• End date: September 27, 2025
• Field of knowledge: Health Sciences - Pharmacy - Pharmaceutical Technology
• Principal Investigator: Gabriel Lima Barros de Araujo
• Grantee: Melissa Viana de Almeida
• Supervisor: Walkiria Santos Schlindwein
• Host Institution: Faculdade de Ciências Farmacêuticas (FCF). Universidade de São Paulo (USP). São Paulo , SP, Brazil
• Institution abroad: De Montfort University, England
• Associated to the scholarship: 24/14953-4 - Development and characterization of amorphous solid dispersions of oxi-chloro telluro anisole, BP.IC

Abstract

Amorphous solid dispersions (ASDs) have proven to be an effective strategy to address the low solubility of many drugs, a common challenge in pharmaceutical development. This project proposes a comparative analysis between the extended Flory-Huggins (xFH) and PC-SAFT models for predicting miscibility and solubility in ASDs. The xFH model incorporates compositional dependence into the drug-polymer interaction parameter, enabling greater accuracy at low drug fractions, while PC-SAFT employs a more detailed thermodynamic approach. Validation will be conducted using experimental data obtained through differential scanning calorimetry (DSC) and solubility tests and literature data for various drug-polymer combinations. By comparing the precision and applicability of both models, this project will contribute to improving ASD design, enhancing the stability and efficacy of pharmaceutical formulations.