Laser-Modified Silver Silicate for Immobilization in Dental Resin: Advancing 3D-Printed Antimicrobial Materials for Dentistry

• Grant number: 25/01424-6
• Support Opportunities: Scholarships abroad - Research Internship - Master's degree
• Start date: September 05, 2025
• End date: March 04, 2026
• Field of knowledge: Physical Sciences and Mathematics - Chemistry - Inorganic Chemistry
• Principal Investigator: Elson Longo da Silva
• Grantee: Ana Luiza de Camargo Doimo
• Supervisor: Gladys Minguez Vega
• Host Institution: Centro de Ciências Exatas e de Tecnologia (CCET). Universidade Federal de São Carlos (UFSCAR). São Carlos , SP, Brazil
• Institution abroad: Universitat Jaume I, Spain
• Associated to the scholarship: 23/10462-3 - Modification of Silver Silicate with Electron Beam for Enhanced Efficacy in Pathogens Elimination, BP.MS

Abstract

The rise of multidrug resistance (MDR) has intensified in recent times, leading to increased mortality associated with infectious diseases. The excessive use of antibioticscontributes to the emergence of resistant microorganisms, driving the search for alternative treatments. Materials such as nanomaterials and metal-based compounds have garnered attention due to their ability to inhibit microbial growth. Silver-based (Ag) materials stand out for their broad-spectrum antimicrobial efficacy. The action of these materials involves the generation of reactive oxygen species (ROS), interference with cell membrane permeability, and the release of Ag+ ions, which cause damage to proteins and DNA. However, metallic silver nanoparticles (AgNPs) face challenges such as uncontrolled ion release, toxicity, and aggregation, whereas Ag-based semiconductors offer a more stable and safer solution by providing controlled ion release and greater compatibility for biomedical applications and the production of advanced antimicrobial materials. Among Ag-based semiconductors, silver silicates stand out for presenting a good balance between efficiency and low cytotoxicity, highlighting their potential for advanced antimicrobial technologies. Femtosecond laser irradiation (FLI) is an environmentally friendly technique capable of enhancing the antimicrobial activity of semiconductors through the development of heterostructures that combine metal and semiconductor, increasing ROS generation. The integration of these materials into dental resins along with 3D printing helps combat infections and provides precise customization, offering a safe and long-lasting solution. The project aims to modify Ag silicates through FLI and encapsulate them in dental resins, seeking to develop advanced composites for 3D printing with enhanced antimicrobial properties and low cytotoxicity. (AU)