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Evaluation of endodontic sealers incorporated with silver vanadate nanostructured decorated with silver nanoparticles for toxicity, antimicrobial and physicochemical properties

Grant number: 17/04667-0
Support type:Scholarships in Brazil - Doctorate
Effective date (Start): May 01, 2017
Effective date (End): December 31, 2019
Field of knowledge:Health Sciences - Dentistry - Dental Materials
Cooperation agreement: Coordination of Improvement of Higher Education Personnel (CAPES)
Principal researcher:Andréa Cândido dos Reis
Grantee:Ana Beatriz Vilela Teixeira
Home Institution: Faculdade de Odontologia de Ribeirão Preto (FORP). Universidade de São Paulo (USP). Ribeirão Preto , SP, Brazil


The development of endodontic sealers with antimicrobial and biocompatible ability to reduce remaining microorganisms in root canals makes association with antimicrobial agents a good option. Silver vanadate nanostructured decorated with silver nanoparticles (AgVO3) is a nanomaterial with antimicrobial capacity and its use associated with endodontic sealers is an innovation not found in the literature. The objective of this project is to evaluate three endodontic sealers (AH Plus, Endomethasone N, Sealer 26) incorporated with AgVO3, in different concentrations (0%, 2.5%, 5% and 10%), through: evaluation of the antimicrobial activity by Direct contact test and cell viability by Confocal Laser Microscopy, against Enterococcus faecalis. Cytotoxicity tests (MTT assay), genotoxicity (Comet test) and mutagenicity (d-H2AX Immunofluorescence), important for assessing the toxicity and biocompatibility of the material.And evaluation of the physico-chemical properties, verifying the surface topography of the pure and modified endodontic cements, evaluation of the solubility, pH and release of silver and vanadium ions of pure cements and modified with AgVO3. For statistical analysis, the distribution and homogeneity of the data will be verified, followed by parametric, non-parametric and descriptive analysis, depending on the distribution, with a significance level of 5% (± = 0.05). (AU)

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Scientific publications
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
TEIXEIRA, ANA BEATRIZ VILELA; DE CASTRO, DENISE TORNAVOI; SCHIAVON, MARCO ANTONIO; DOS REIS, ANDREA CANDIDO. Cytotoxicity and release ions of endodontic sealers incorporated with a silver and vanadium base nanomaterial. ODONTOLOGY, . (17/04667-0)
VILELA TEIXEIRA, ANA BEATRIZ; HONORATO SILVA, CAROLINE DE CARVALHO; ALVES, OSWALDO LUIZ; DOS REIS, ANDREA CANDIDO. Endodontic Sealers Modified with Silver Vanadate: Antibacterial, Compositional, and Setting Time Evaluation. BIOMED RESEARCH INTERNATIONAL, . (17/04667-0)
TEIXEIRA, ANA B. V.; MOREIRA, NATALIA C. S.; TAKAHASHI, CATARINA S.; SCHIAVON, MARCO A.; ALVES, OSWALDO L.; REIS, ANDREA C.. Cytotoxic and genotoxic effects in human gingival fibroblast and ions release of endodontic sealers incorporated with nanostructured silver vanadate. JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART B-APPLIED BIOMATERIALS, v. 109, n. 9, p. 1380-1388, . (17/04667-0)

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