Study of the incorporation of virus-like particles into SBA-15: an analysis with circular dichroism.

• Grant number: 25/05112-9
• Support Opportunities: Scholarships in Brazil - Scientific Initiation
• Start date: May 01, 2025
• End date: April 30, 2026
• Field of knowledge: Physical Sciences and Mathematics - Physics - Condensed Matter Physics
• Principal Investigator: Jose Luiz de Souza Lopes
• Grantee: Ane Okuda Igarashi
• Host Institution: Faculdade de Filosofia, Ciências e Letras de Ribeirão Preto (FFCLRP). Universidade de São Paulo (USP). Ribeirão Preto , SP, Brazil
• Associated research grant: 22/01951-8 - Study of the chemical and structural integrity of virus-like particles and their incorporation into ordered mesoporous silica, AP.PNGP.PI

Abstract

In this project, we aim to incorporate virus-like particles and antigenic proteins into ordered mesoporous silica particles, such as SBA-15 and others synthesized by us (containing different surface functionalizations), and employ the spectroscopy of circular dichroism to investigate the secondary structure of these proteins when incorporated into mesoporous silica.