Advanced Diagnostic and Surveillance Strategies for Newcastle Disease Virus (NDV) in the State of São Paulo

• Grant number: 25/02282-0
• Support Opportunities: Scholarships in Brazil - Post-Doctoral
• Start date: July 01, 2025
• End date: June 30, 2028
• Field of knowledge: Biological Sciences - Microbiology - Applied Microbiology
• Principal Investigator: Helena Lage Ferreira
• Grantee: Andreina de Carvalho Araujo
• Host Institution: Faculdade de Zootecnia e Engenharia de Alimentos (FZEA). Universidade de São Paulo (USP). Pirassununga , SP, Brazil

Abstract

The virulent Newcastle Disease Virus (NDV) poses a significant threat to global poultry production due to its high transmissibility, letality, and economic impact. This project proposes the development of a lateral flow immunochromatographic test for the rapid differentiation between virulent and non-virulent isolates, contributing to immediate outbreak response. Additionally, it aims to genetically characterize emerging variants through complete viral genome sequencing, enabling the identification of mutations associated with pathogenicity. Risk analysis of NDV introduction and dissemination in São Paulo state will be conducted based on molecular, serological, and epidemiological data, guiding biosecurity strategies. Integrated approaches involving molecular biology, bioinformatics, and epidemiology will generate essential data to strengthen surveillance, disease control, and the protection of Brazilian poultry farming, a sector of global significance. (AU)