Uptake and survival assays of Salmonella Gallinarum, Salmonella Pullorum and Salmonella Enteritidis strains during the infection of macrophage-like chicken cells type HD11.

• Grant number: 25/10691-8
• Support Opportunities: Scholarships in Brazil - Scientific Initiation
• Start date: July 01, 2025
• End date: June 30, 2026
• Field of knowledge: Agronomical Sciences - Veterinary Medicine - Animal Pathology
• Principal Investigator: Mauro de Mesquita Souza Saraiva
• Grantee: Rafaela Lemos de Carvalho
• Host Institution: Faculdade de Ciências Agrárias e Veterinárias (FCAV). Universidade Estadual Paulista (UNESP). Campus de Jaboticabal. Jaboticabal , SP, Brazil
• Associated research grant: 23/07046-8 - Evaluation of behavior of Salmonella Gallinarum, Salmonella Pullorum, and Salmonella Enteritidis strains during chicken-primary-macrophage infection, AP.JP

Abstract

Salmonella Gallinarum (SG) and Salmonella Pullorum (SP) are among the most prevalent serovars found in poultry, causing significant economic losses, along with Salmonella Enteritidis (SE), one of the main causes of foodborne infections in humans. In commercial poultry, during the disease pathogenesis, the bird's innate immunity plays an essential role, since Salmonella, through virulence mechanisms, is able to establish and multiply inside macrophages, resulting in dissemination to other organs such as the spleen and liver. Therefore, it is important to understand how these pathogens evade the host's innate defense, establishing systemic infections. In this study, we propose to evaluate the capture and survival of SG, SP and SE in macrophage-like chicken cells type HD11. (AU)