| Grant number: | 16/10369-0 |
| Support Opportunities: | Regular Research Grants |
| Start date: | September 01, 2016 |
| End date: | February 28, 2019 |
| Field of knowledge: | Agronomical Sciences - Veterinary Medicine - Animal Pathology |
| Principal Investigator: | Angelo Berchieri Junior |
| Grantee: | Angelo Berchieri Junior |
| Host Institution: | Faculdade de Ciências Agrárias e Veterinárias (FCAV). Universidade Estadual Paulista (UNESP). Campus de Jaboticabal. Jaboticabal , SP, Brazil |
| City of the host institution: | Jaboticabal |
| Associated researchers: | Oliveiro Caetano de Freitas Neto ; Rafael Antonio Casarin Penha Filho |
Abstract
The aviculture is an important segment of animal production. The intensive system favours the emergence of various infections, like salmonellosis. The fowl typhoid, caused by Salmonella Gallinarum biovar Gallinarum (SG) causes high mortality rate on the flock, whereas Salmonella Enteritidis (SE) and Salmonella Typhimurium (ST) outcomes in disorders to the poultry production because may induce disease in poultry and, through food poultry origin, to provokehuman foodborne disease.Soto take systemic infection, SG has to invade the host, to evade the antimicrobial activity of the macrophages and to multiply inside the phagossomes, being indispensable the activation of the pleiotropic two-component regulatory system PhoP/PhoQ during the process. On the other hand, the previous recognition of flagellin of paratyphoid salmonellosis by the intestinal TLR-5 receptors may turns the systemic infection into mild. With the purpose to evaluate the infection of mutant strains SGphoPQ, SEfliDclpP and STfliDclpP, two assays will be performed in susceptible poultry. The first one aims to survey the effect caused by the deletion of phoP and phoQ (SGphoPQ) genes on SG pathogenicity and, in case of the strain is attenuated, itsabilityto induce protection to poultry against fowl typhoid and fowl paratyphoid caused by SE will be evaluated. The assay will be based on the evaluation of intestinal colonisation, systemic infection and the characterization of the activity of macrophages and lymphocytes in poultry inoculated with strains SEfliDclpP and STfliDclpP will be performed. (AU)
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