Multifunctional composites consisting of phytoactives intercalated in layered hydroxide and biocompatible polymer

• Grant number: 25/09631-0
• Support Opportunities: Scholarships in Brazil - Scientific Initiation
• Start date: July 01, 2025
• End date: June 30, 2026
• Field of knowledge: Physical Sciences and Mathematics - Chemistry - Inorganic Chemistry
• Principal Investigator: Vera Regina Leopoldo Constantino
• Grantee: Verônica Costa Biselli
• Host Institution: Instituto de Química (IQ). Universidade de São Paulo (USP). São Paulo , SP, Brazil

Abstract

The critical properties that determine the success of a drug candidate include solubility, permeability, metabolic stability, and transport effects. To enhance the efficacy of bioactive molecules, researchers explore new formulations through strategies like developing drug delivery systems (DDSs). The main objective of this project is to utilise nanomaterials containing cinnamic acid (Cin) intercalated in layered zinc hydroxide (LZH) as a DDS to improve the solubility and chemical stability of a model molecule, curcumin (Cur). We will assess the success of the DDS preparation by determining the bioactive compound's efficiency and loading capacity. Characterization techniques such as X-ray diffractometry, thermogravimetric analysis, vibrational spectroscopy, and electronic absorption spectroscopy will be employed. The organic-inorganic hybrid particle DDS will be combined with sodium alginate to create films. These films will be characterised using structural, spectroscopic, and mechanical techniques and by evaluating swelling, degradability, and the release of phytoactives (cinnamate and curcumin) in a simulated physiological medium. Finally, biological tests will assess the composite's suitability as a topical delivery system for bioactives. This project lays the groundwork for studying other phytotherapeutic agents with low solubility and/or chemical stability, but high therapeutic potential, by employing the proposed strategy for the carrier's design.