Interneuron population in the hippocampal sclerosis type 2

• Grant number: 25/23302-0
• Support Opportunities: Scholarships in Brazil - Program to Stimulate Scientific Vocations
• Start date: January 26, 2026
• End date: March 12, 2026
• Field of knowledge: Health Sciences - Medicine - Medical Clinics
• Principal Investigator: Ésper Abrão Cavalheiro
• Grantee: Gilson Alfredo Ferreira Brum
• Host Institution: Escola Paulista de Medicina (EPM). Universidade Federal de São Paulo (UNIFESP). Campus São Paulo. São Paulo , SP, Brazil

Abstract

Mesial temporal lobe epilepsy is the most common form of difficult-to-treat focal epilepsy in adults, and hippocampal sclerosis is observed in most patients.Recently, it has been described that patients with type 2 sclerosis present with preserved memory; however, up to 25% of these patients have long-term memory deficits. Since the patterns of hippocampal sclerosis are defined according to the loss of principal neurons, the objective of this proposal will be to investigate whether the hippocampal density of parvalbumin-positive and calretinin-positive interneurons correlates with the mnemonic performance of patients with type 2 hippocampal sclerosis.