Development of Biopolymeric Cryogels Based on Mangaba Tree Latex and Nanocellulose for Bone Regeneration with Emphasis on the Valorization of Brazilian Genetic Heritage and Traditional Knowledge

• Grant number: 25/20477-3
• Support Opportunities: Scholarships in Brazil - Doctorate (Direct)
• Start date: June 01, 2026
• End date: May 31, 2031
• Field of knowledge: Physical Sciences and Mathematics - Chemistry
• Principal Investigator: Rubia Figueredo Gouveia
• Grantee: Beatriz Borges Ribeiro
• Host Institution: Centro Nacional de Pesquisa em Energia e Materiais (CNPEM). Campinas , SP, Brazil
• Associated research grant: 24/00989-7 - Research Center of Molecular Engineering for Advanced Materials (CEMol), AP.CEPID

Abstract

Given the demand for materials that integrate technology and socio-environmental responsibility, biopolymers emerge as relevant alternatives. In this context, the use of composites derived from renewable sources with potential social impact becomes a viable strategy. Therefore, this project proposes the development and characterization of hybrid cryogels based on mangaba tree latex (Hancornia speciosa) and cellulose nanofibrils (CNFs) extracted from sugarcane bagasse, targeting applications in bone tissue regeneration. The research emphasizes the valorization of the traditional mangaba tree extraction practices, historically carried out by women and recognized as Intangible Cultural Heritage of the State of Sergipe, Brazil. Mangaba tree latex presents documented bioactive properties, such as angiogenic activity, anti-inflammatory effects, and biocompatibility, while CNF, obtained from lignocellulosic residues, contributes with favorable physicomechanical properties, colloidal stability, and surface at functionalization. The methodology includes a critical analysis of extraction practices, production, and physicochemical characterizations of the cryogels. Since cellulose is highly hydrophilic, challenges will be addressed in order to obtain a three-dimensional material structurally resilient to physiological and aqueous media. The expectation is that the combination of these materials will result in a system with tunable properties according to the intended biomedical application, promoting a natural alternative socially intertwined with traditional communities. (AU)