Evaluation of the in vitro antischistossomial and trypanocidal activities of the dihydrobenzofuran lignans and neolignans

• Grant number: 08/01174-4
• Support Opportunities: Scholarships in Brazil - Scientific Initiation
• Start date: September 01, 2008
• End date: August 31, 2009
• Field of knowledge: Health Sciences - Pharmacy - Pharmacognosy
• Principal Investigator: Ademar Alves da Silva Filho
• Grantee: Ubirajara Oliveira Gonçalves
• Host Institution: Pró-Reitoria Adjunta de Pesquisa e Pós-Graduação. Universidade de Franca (UNIFRAN). Franca , SP, Brazil

Abstract

Lignans e neolignans have attracted much interest over the years on account of their broad range of biological activities. Previous biological activities showed that tetrahydrofuran and dibenzyl butyrolactone lignans possess in vitro and in vivo antischistosomal activities. Then, the aims of this project are: to obtain the dihydrobenzofuran lignans and neolignans 1, 2a, and 2b, as well as to evaluate the in vitro antischistosomal and trypanocidal activities of these synthesized compounds. These compounds will be obtained by in vitro oxidative coupling using different phenylpropanoids. After synthesized, these compounds will be purified using several techniques, including chromatographic methods, and identified by spectroscopic analysis (p. ex. RMN 1H and 13C). All obtained compounds will be evaluated in the in vitro antischistosomal and trypanocidal assays.(AU)