Participation of IL-17 how molecular marker of clinical forms of Chagas' disease

• Grant number: 07/04896-8
• Support Opportunities: Scholarships in Brazil - Post-Doctoral
• Start date: January 01, 2009
• End date: January 31, 2010
• Field of knowledge: Biological Sciences - Immunology - Applied Immunology
• Principal Investigator: João Santana da Silva
• Grantee: Paulo Marcos da Matta Guedes
• Host Institution: Faculdade de Medicina de Ribeirão Preto (FMRP). Universidade de São Paulo (USP). Ribeirão Preto , SP, Brazil

Abstract

IL-17 is involved in immunopathogenesis of several autoimmune diseases (rheumathoid arthritis, encephalitis autoimmunity) and recently in parasitary diseases (toxoplasmosis and schistosomiasis, tuberculosis). The IL-17 participation in modulation or induction of chagasic miocarditis are not knows. The better understanding about immune mechanism involved in resistance to infection or lesion genesis in Chagas disease, how IL-17 function, maybe be used to reduce the morbidity during chronic phase of Chagas disease and therapeutic strategies. In the present work we will be evaluate the immune response, mainly Th17 response, in chagasic patients with indeterminate and cardiac forms of Chagas disease, before and one year after specific therapeutic using benznidazole. We will also evaluate the mechanisms involved in the IL-17 production in vitro using peripheral blood mononuclear cells of chagasic patients and healthful voluntaries using specific stimulation. Previous research in our laboratory indicated that chagasic patients with severe cardiophaty produced more IL-17 than patients with mild cardiophaty and not infected people. Besides, we observed the IL-17 participation in heart inflammatory process during acute phase of murine Chagas disease. (AU)

Scientific publications

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

FREDY RS GUTIERREZ; TIAGO WP MINEO; WANDER R PAVANELLI; PAULO MM GUEDES; JOÃO S SILVA. The effects of nitric oxide on the immune system during Trypanosoma cruzi infection. Memórias do Instituto Oswaldo Cruz, v. 104, p. 236-245, 2009-07-00. (06/06803-4, 07/04896-8, 07/53940-0)