Despite all the scientific advances in recent decades in order to unravel the host immune processes and the circumvention of the parasite, Chagas disease is still a major public health problem, affecting approximately 20 million people throughout Latin America. The corresponding Brazil for about 3,5 million patients with Chagas disease. Demographic projections estimate an increase in the proportion of elderly in Brazil, where the number of individuals over 60 years old may exceed 30 million. The immune activity, and most physiologic functions decline with age, and the theoretical explanation of the aging process. There are few studies on Chagas disease in the elderly and is most of the clinical aspects of the disease, therefore, the present study aims to evaluate the effects of immunosenescence male Wistar rats experimentally infected by Trypanosoma cruzi Y strain, and thus, study the cellular and molecular alterations involved in the lifelong immunity and their reflections in the acute phase of Chagas disease mechanisms. Studies will be carried out in 9 and 16 after infection, using the parameter: parasite count; dose of IL-2, IL-4, IL-6, IL-10 IL-12, IL-17, IFN-³, TGF-², TNF-± and nitric oxide; participation of cell populations CD3, CD4, CD8, CD11a, CD25, CD27, CD28, CD80, CD45RA, CD86, CD161, FoxP3, RT1B, including macrophages, dendritic cells and Natural Killer cells (NK); proliferation and apoptosis of spleen cells and the production of corticosterone and dehydroepiandrosterone (DHEA).
News published in Agência FAPESP Newsletter about the scholarship: