Synthesis of isotetronic acids and goniothalamin analogues and evaluation of their cytotoxic activity against cancer cell lines

• Grant number: 09/06060-0
• Support Opportunities: Scholarships in Brazil - Post-Doctoral
• Start date: September 01, 2009
• End date: November 30, 2009
• Field of knowledge: Physical Sciences and Mathematics - Chemistry - Organic Chemistry
• Principal Investigator: Ronaldo Aloise Pilli
• Grantee: Júlio Cezar Pastre
• Host Institution: Instituto de Química (IQ). Universidade Estadual de Campinas (UNICAMP). Campinas , SP, Brazil

Abstract

The synthesis of goniothalamin analogues containing the g-butyrolactone moiety will be carried out and their citotoxic activity will be evaluated against a panel of human cancer cell lines. The asymmetric syntheses of isotetronic acids and the lower homologues of goniothalamin, herein denominated as homogoniothalamins, will be investigated employing organocatalysis, chiral Bronsted acids and diastereoselective Michael addition. (AU)