Computational methods for characterization and analysis of neurons and glias

• Grant number: 07/02938-5
• Support Opportunities: Scholarships in Brazil - Post-Doctoral
• Start date: January 01, 2008
• End date: December 31, 2009
• Field of knowledge: Physical Sciences and Mathematics - Computer Science - Computing Methodologies and Techniques
• Principal Investigator: Luciano da Fontoura Costa
• Grantee: Bruno Augusto Nassif Travençolo
• Host Institution: Instituto de Física de São Carlos (IFSC). Universidade de São Paulo (USP). São Carlos , SP, Brazil

Abstract

The objective of this project is the development and application of computational methods to study the development of neurons and glias. The main motivation of this study is to gain new insights about the relationship between shape, function and gene expression in these cells. The analysis will be made through the use of microscopy images of biological samples, captured in two and three dimensions, to which image processing, shape analysis and computer visualization routines will be applied. Therefore, it will be possible to characterize the morphologic and gene expression aspects in neurons and glias and correlate these features with the development and function of these cells.

Scientific publications

(9)

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

COMIN, CESAR H.; BATISTA, JOAO L. B.; VIANA, MATHEUS P.; COSTA, LUCIANO DA F.; TRAVENCOLO, BRUNO A. N.; KAISER, MARCUS. STRUCTURE AND DYNAMICS: THE TRANSITION FROM NONEQUILIBRIUM TO EQUILIBRIUM IN INTEGRATE-AND-FIRE DYNAMICS. INTERNATIONAL JOURNAL OF BIFURCATION AND CHAOS, v. 22, n. 7, JUL 2012. (05/00587-5, 07/02938-5)

TRAVENCOLO, B. A. N.; COSTA, L. DA F.. Accessibility in complex networks. Physics Letters A, v. 373, n. 1, p. 89-95, DEC 22 2008. (05/00587-5, 07/02938-5)

VIANA, MATHEUS PALHARES; TRAVENCOLO, BRUNO A. N.; TANCK, ESTHER; COSTA, LUCIANO DA FONTOURA. Characterizing topological and dynamical properties of complex networks without border effects. PHYSICA A-STATISTICAL MECHANICS AND ITS APPLICATIONS, v. 389, n. 8, p. 1771-1778, APR 15 2010. (05/00587-5, 07/02938-5, 07/50882-9)

HOLLOWAY, DAVID M.; LOPES, FRANCISCO J. P.; COSTA, LUCIANO DA FONTOURA; TRAVENCOLO, BRUNO A. N.; GOLYANDINA, NINA; USEVICH, KONSTANTIN; SPIROV, ALEXANDER V.. Gene Expression Noise in Spatial Patterning: hunchback Promoter Structure Affects Noise Amplitude and Distribution in Drosophila Segmentation. PLOS COMPUTATIONAL BIOLOGY, v. 7, n. 2, p. e1001069, 2011. (07/02938-5)

TRAVENCOLO, BRUNO A. N.; VIANA, MATHEUS PALHARES; COSTA, LUCIANO DA FONTOURA. Border detection in complex networks. NEW JOURNAL OF PHYSICS, v. 11, JUN 12 2009. (05/00587-5, 07/02938-5, 07/50882-9)

COSTA, L. DA F.; TRAVENCOLO, B. A. N.; VIANA, M. P.; STRANO, E.. On the efficiency of transportation systems in large cities. EPL, v. 91, n. 1, JUL 2010. (05/00587-5, 07/02938-5, 07/50882-9)

SILVA, FILIPI NASCIMENTO; TRAVENCOLO, BRUNO A. N.; VIANA, MATHEUS P.; COSTA, LUCIANO DA FONTOURA. Identifying the borders of mathematical knowledge. Journal of Physics A-Mathematical and Theoretical, v. 43, n. 32, AUG 13 2010. (05/00587-5, 07/02938-5, 07/50882-9)

TREMBLAY, MARC; FUGERE, VINCENT; TSUI, JENNIFER; SCHOHL, ANNE; TAVAKOLI, AYDIN; TRAVENCOLO, BRUNO A. N.; COSTA, LUCIANO DA F.; RUTHAZER, EDWARD S.. Regulation of Radial Glial Motility by Visual Experience. JOURNAL OF NEUROSCIENCE, v. 29, n. 45, p. 14066-14076, NOV 11 2009. (05/00587-5, 07/02938-5)

HOLLOWAY, DAVID M.; LOPES, FRANCISCO J. P.; COSTA, LUCIANO DA FONTOURA; TRAVENCOLO, BRUNO A. N.; GOLYANDINA, NINA; USEVICH, KONSTANTIN; SPIROV, ALEXANDER V.. Gene Expression Noise in Spatial Patterning: hunchback Promoter Structure Affects Noise Amplitude and Distribution in Drosophila Segmentation. PLOS COMPUTATIONAL BIOLOGY, v. 7, n. 2, p. 18-pg., 2011-02-01. (07/02938-5, 05/00587-5)